BACKGROUND Myocardial potassium channels are complexes formed by different subunits. The subunit composition may influence the cardiotoxic action of local anaesthetics. The effects of amide local anaesthetics on HERG channels co-expressed with the putative subunit MiRP1 have not been established. It is also unclear if the common polymorphism MiRP1(T8A) that predisposes individuals to drug-induc...

BACKGROUND Despite the large amount of literature on caudal anaesthesia in children, the issue of volume of local anaesthetics and cranial spread is still not settled. Thus, the aim of the present prospective randomized study was to evaluate the cranial spread of caudally administered local anaesthetics in children by means of real-time ultrasound, with a special focus on the effects of using d...

Editor, To achieve extended anaesthesia and analgesia, a psoas compartment–sciatic nerve block (PCSNB) requires administration of large volumes of potentially cardiotoxic local anaesthetics. Due to the anatomic location of the lumbar plexus [1], mostly within muscle tissue, initial absorption of the administered local anaesthetics after a psoas compartment block could result in relatively high ...

BACKGROUND AND OBJECTIVE Previous studies regarding the effects of some local anaesthetics have suggested that these agents can cause genetic damage. However, they have not been tested for genotoxicity related to repetitive administration. The aim of this study was to evaluate the genotoxic potential of local anaesthetics upon repetitive administration. METHODS 80 male Wistar rats were divide...