Aspirations or Jamshidi needle biopsies (n = 287) of bone marrow were performed on children and adolescents with acute leukemia or other malignant disease following the use of a spring-loaded instrument that delivered local anesthetic in a jet spray; 89% of the patients were receiving chemotherapy, 12% were thrombocytopenic, and 23% of the 269 patients who were afebrile at the time of the proce...

Local infiltration analgesia (LIA) is an analgesic technique that has gained popularity since it was first brought to widespread attention by Kerr and Kohan in 2008. The technique involves the infiltration of a large volume dilute solution of a long-acting local anesthetic agent, often with adjuvants (e.g., epinephrine, ketorolac, an opioid), throughout the wound at the time of surgery. The ana...

Introduction: We previously reported a case using caudal morphine for pediatric liver transplantation. A 3-yr-old, 14.9 kg child received a caudal injection of 0.6 mg of preservative free morphine sulfate as well as 110 mcg of intravenous fentanyl. Also, the surgical incisions were infiltrated with 20 ml of 0.125% bupivacaine1. However, a question arose as to the impact of the local anesthetic ...

OBJECTIVE To assess the efficacy of wound infiltration with local anesthetic in reducing postoperative pain after a muscle-splitting incision for appendectomy. DESIGN A double-blind, placebo-controlled, randomized clinical trial. SETTING The Royal Columbian Hospital, a university-affiliated community hospital. PARTICIPANTS Forty-three patients scheduled to undergo emergency appendectomy w...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

Introduction: Port site and subdiaphragmatic infiltration of local anesthetics during laparoscopic cholecystectomy (LC) is preferred by surgeons to decrease postoperative pain. LC with as well without any anesthetic both have been standard surgical practice. However, the difference in reduction pain these two groups not known. The objective study was compare at port space LC.
 
 Metho...

Stellate ganglion blockade (SGB) with a local anesthetic increases muscle sympathetic nerve activity in the tibial nerve in humans. However, whether this sympathetic excitation in the tibial nerve is due to a sympathetic blockade in the neck itself, or due to infiltration of a local anesthetic to adjacent nerves including the vagus nerve remains unknown. To rule out one mechanism, we examined t...