The local mechanical properties of DNA are believed to play an important role in their biological functions and DNA-based nanomechanical devices. Using a simple sphere-tip compression system, the local radial mechanical properties of DNA are systematically studied by changing the tip size. The compression simulation results for the 16 nm diameter sphere tip are well consistent with the experime...

Double pulsed-field gradient (d-PFG) MRI can provide quantitative maps of microstructural quantities and features within porous media and tissues. We propose and describe a novel MRI phantom, consisting of wafers of highly ordered glass capillary arrays (GCA), and its use to validate and calibrate a d-PFG MRI method to measure and map the local pore diameter. Specifically, we employ d-PFG Spin-...

BACKGROUND A proven advantage of radial over femoral arterial access has led to an increase in the number of interventions performed via radial artery access in patients with acute coronary syndromes. Both assessment of the pulse volume and the Allen's test are subjective and subject to investigator bias. An ultrasound examination of the forearm arteries provides important information about the...

C oronary vasoregulation, the control of coronary artery diameter and blood flow, is an important and complex physiological function in which the endothelium plays a key role.' Many chemical and mechanical stimuli affect numerous endothelial cell receptors, triggering multiple signal transduction mechanisms and resulting in the release of several local activators.2 The net effects on coronary a...

Radiofrequency ablation (RFA) is a new local therapy for hepatocellular carcinoma (HCC). In this study, we investigated the risk factors associated with local recurrence of HCC after single-session RFA with a single electrode insertion. From April 2003 to December 2007, we treated 138 HCC lesions by single-session RFA with a single electrode insertion using the Cool-tip RFA, RTC 2000 and RTC 30...

Objective The feasibility and usefulness of transradial catheterization for coronary and neuro-intervention are well known. However, the anatomical change in the catheterized radial artery (RA) is not well understood. Herein, we present the results of ultrasonographic observation of the RA after routine transradial cerebral angiography (TRCA). Methods Patients who underwent routine TRCA with ...

One of the most widely used non-invasive clinical metric for diagnosing patients with symptoms of coronary artery disease is %stenosis derived from cCTA. Estimation of %stenosis involves two steps the measurement of local diameter and the measurement of a reference healthy diameter. The estimation of a reference healthy diameter is challenging, especially in diffuse, ostial and bifurcation lesi...