ANRIL (Antisense Noncoding RNA in the INK4 Locus), a long non-coding encoded human chromosome 9p21 region, is critical factor for regulating gene expression by interacting with multiple proteins and miRNAs. It has been found to play important roles various cellular processes, including cell cycle control proliferation. Dysregulation of associated several diseases like cancers cardiovascular dis...

objective(s): similar characteristics of molecular pathways between cellular reprogramming events and tumorigenesis have been accentuated in recent years. reprogramming-related transcription factors, also known as yamanaka factors (oct4, sox2, klf4, and c-myc), are also well-known oncogenes promoting cancer initiation, progression, and cellular transformation into cancer stem cells. long non-co...