A new multistage stochastic mine production scheduling approach is developed and tested in a large operating gold mine. The approach takes short scale orebody information in the form of grade control data into account. As simulated orebodies used in stochastic long term mine planning are based on sparse exploration data while grade control data are unavailable at the time of production scheduli...

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded b...

conclusions the stereotactic brachytherapy for patients with circumscribed and relatively small size tumors appears to be a safe, feasible, and minimally-invasive treatment. results thirteen patients were male and 16 were female, with the median age of 29 years (range, 2.5 – 64 years). the median follow-up was 95 (range, 6 – 240) months. based on pignatti classification, 10 patients were at low...

Short-term production plans are the basis for operational mine production schedules. They concentrate on making long-term mine plans operationally feasible. Furthermore, some variables such as ore grade and tonnage govern mine production systems and cause uncertainty in the supply of raw materials to the mills. Due to the quality variation of material, short-term production optimization is an u...

optimization models have been used to support decision making in production planning for a long time. however, several of those models are deterministic and do not address the variability that is present in some of the data. robust optimization is a methodology which can deal with the uncertainty or variability in optimization problems by computing a solution which is feasible for all possible ...

introduction: stress is associated with neurological and cognitive disorders. it has been suggested that doxepin, in addition to its influence on the content of neurotransmitters, has probable neuroprotective effects as well. therefore, the aim of this study was to investigate the effects of doxepin on synaptic plasticity and brain-derived neurotrophic factor (bdnf) gene expression in the rat h...

long-term potentiation (ltp) is a reflection of synaptic plasticity that induced by specific patterns of synaptic activity and has an important role in learning and memory. the first clue of the potential role of glutamate receptors in ltp was in 1991 with the observation that the mglur agonists 1-amino-1, 3-cyclopentanedicarboxylic acid (acpd), increased ltp. studies have shown that acpd induc...

Future generation cellular networks are expected to deliver an omnipresent broadband access network for an endlessly increasing number of subscribers. Long term Evolution (LTE) represents a significant milestone towards wireless networks known as 4G cellular networks. A key feature of LTE is the implementation of enhanced Radio Resource Management (RRM) mechanism to improve the system performan...