Adaptive systems are able to modify their behaviors to respond to significant changes at run time such as component failures. In many cases, run-time adaptation is simply replacing a piece of system with a new one without interrupting the system operation. In terms of component-based systems, an adaptation may be defined as replacing a system component with a new version at run time. However, u...

In contrast to earlier concepts, it seems that distinct ligands acting on the same receptor may elicit qualitative different response patterns, a phenomenon given many names, including "functional selectivity," "agonist-directed trafficking," "biased agonism," "protean agonism," or "ligand-directed signaling." In this issue of Molecular Pharmacology, Sato et al. (p. 1359) extend this concept to...

This article considers Richard Rolle's use of erotic imagery and romantic metaphor in his popular fourteenth-century devotional manual, The Form of Living. The Form engaged a widespread community of readers through the glorification of desire and pleasure, which were sanctified by merit of Christ, the lover that Rolle encouraged his readers to woo. While the use of language in the text is inclu...

We give the first example of systolic freedom over torsion coefficients. The phenomenon is a bit unexpected (contrary to a conjecture of Gromov’s) and more delicate than systolic freedom over the integers. Dedicated to Rob Kirby, a lover of Mathematics and other wild places. Thank you for your inspiration. AMS Classification 53C22

In this paper, we describe a motivation to develop an Android mobile application for a wine lover. We introduce a simple map of concepts used for analysis and modeling of the subject domain. We also briefly describe the application architecture and the interfaces developed to support major use cases that a wine amateur may require in order to store and manage information about wines.