نتایج جستجو برای: low bioavailable drug
تعداد نتایج: 1728796 فیلتر نتایج به سال:
Biogeosciences Discussions This discussion paper is/has been under review for the journal Biogeosciences (BG). Please refer to the corresponding final paper in BG if available. Abstract Dissolved organic carbon (DOC) and total dissolved amino acids (TDAA) were measured in high (Chukchi Sea) and low (Beaufort Sea) productivity regions of the Western Arctic Ocean to investigate the composition an...
Testosterone deficiency is a common and often unrecognized disorder impacting the lives of many men. Symptoms related to low testosterone are relatively non-specific and clinicians must therefore ensure that a patients' symptomatology is supported by a biochemical profile suggestive of testosterone deficiency. There are many options available to determine a patient's testosterone level and labo...
The use of inorganic fertilizers and pesticides can trigger the presence heavy metals that pollute agricultural land. purpose this study was to determine bioavailability Pb Cu in cayenne pepper farms Subak Sembung plantation Denpasar as well bioaccumulation each part plant. method used fractions a squential extraction method, while by destruction quantified using Atomic Absorption Spectrometry ...
OBJECTIVES The present study aimed to determine the prevalence and etiology of erectile dysfunction in Saudi type 2 diabetic patients. PATIENTS AND METHODS 429 Saudi type 2 diabetic male patients aged more than 30 years were recruited. Total and bio-available serum testosterone, sex hormone binding globulin and free testosterone levels were measured by ELISA-IBL GMBH Germany. RESULTS 47 (12...
One of the major challenges facing cancer therapy today is achieving specificity. Current efforts to meet this challenge are focused on developing targeted therapeutics specific to the cancer cell. An alternative approach is to selectively deliver cytotoxic agents to the tumor site. With this end in mind, liposomes optimized for physical robustness have been developed and used clinically as dru...
Although the multiplicity in transport proteins assessed during drug development is continuously increasing, the clinical relevance of the breast cancer resistance protein (BCRP) is still under debate. Here, our aim is to rationalize the need to consider BCRP substrate and inhibitor interactions and to define optimum selection and acceptance criteria between cell-based and vesicle-based assays ...
Abstract Background The most well-known cause of cancer deaths identified in female is breast cancer. Several drugs approved by the food and drug administration (FDA) for treatment may have adverse health effects. This research aimed at developing a QSAR model utilize it to predict inhibitive activities newly designed novel compounds, examine their ADMET drug-likeness properties carry out molec...
Abstract In the pharmaceutical market, need to find effective systems for efficient release of poorly bioavailable drugs is a forefront topic. The inorganic–organic hybrid materials have been recognized as one most promising systems. this paper, we developed new Hydroxypapatite@Furosemide hybrids with improved dissolution rates in different media respect drug alone. formation was demonstrated b...
The Ras/Raf/MEK/ERK signal transduction, an oncogenic pathway implicated in a variety of human cancers, is a key target in anticancer drug design. A novel series of pyrimidylpyrrole ERK inhibitors has been identified. Discovery of a conformational change for lead compound 2, when bound to ERK2 relative to antitarget GSK3, enabled structure-guided selectivity optimization, which led to the disco...
In two montane watersheds that receive minimal deposition of atmospheric nitrogen, 15–71% of dissolved organic nitrogen (DON) was bioavailable in stream water over a 2-year period. Discharge-weighted concentrations of bulk DON were between 102 and 135 lg/l, and the C:N ratio differed substantially between humic and non-humic fractions of DON. Approximately 70% of DON export occurred during snow...
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