Bone mass accrual is a major determinant of skeletal mass, governed by bone remodeling, which consists of bone resorption by osteoclasts and bone formation by osteoblasts. Bone mass accrual is inhibited by sympathetic signaling centrally regulated through activation of receptors for serotonin, leptin, and ACh. However, skeletal activity of the parasympathetic nervous system (PSNS) has not been ...

Puberty is a crucial time for bone development with a doubling of skeletal mass and at least 90% of bone mineral deposition accrued by the end of adolescence [1]. Following puberty, bone mineral deposition continues with peak bone mass typically obtained around the age of 25 years [2]. The accrual of bone mass during adolescence is a major determinant of peak bone mass [1] and low peak bone mas...

Abstract Background In Acute Myeloid Leukemia (AML), malignant clones of immature myeloid cells (primarily blasts) proliferate, replace bone marrow, circulate in blood and invade other tissues. The unique presentation of unilateral ptosis and unilateral eyelid swelling in AML has been reported during the present study. Case Report A 7-year-old girl was encountered with progressively increa...

conclusions the findings indicated that older women with low bmi were at higher risk of low bone mass. body weight, bmi and aging may be important predictors of bmd, but they are not the only factors affecting bone loss. therefore, it is recommended to assess other risk factors with a larger number of patients. results the mean bmd of women older than 50 years compared to those younger than 50 ...

Tryptophan, an essential amino acid through a series of enzymatic reactions gives rise to various metabolites, viz. serotonin and melatonin, that regulate distinct biological functions. We show here that tryptophan metabolism in the pineal gland favors bone mass accrual through production of melatonin, a pineal-derived neurohormone. Pineal gland-specific deletion of Tph1, the enzyme that cataly...

osteoporosis as a skeletal disorder characterize by compromised bone strength predisposing a person to an increased risk of fracture. all people should be encouraged to take efforts to prevent bone loss and fractures. nutrition is one of several factors that can be modified to reduce osteoporosis risk. the purpose of this review article is assessment the role of the other nutrients the exceptio...

OBJECTIVE Osteopenia is a common complication of juvenile idiopathic arthritis (JIA). In adults, low bone density and increased fracture risk are associated with low vitamin K status of bone. The vitamin K-dependent protein osteocalcin plays an important role in bone metabolism. Its activity depends upon post-translational carboxylation in which vitamin K is an essential co-factor. Hence, vitam...

Background: Failure to maintain bone mass density is a major complication in patients with cystic fibrosis (CF). This study was conducted to evaluate the prevalence of low bone mineral density (BMD) and also identifying associated risk factors in CF patients. Materials and Methods: Present study conducted on 59 CF patients aged 5-35 years referred to respiratory clinic of Masih Daneshvari Hospi...