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Tissue glucocorticoid levels in the liver and adipose tissue are regulated by regeneration of inactive glucocorticoid by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and inactivation by 5alpha- and 5beta-reductases. A low carbohydrate diet increases hepatic 11beta-HSD1 and reduces glucocorticoid metabolism during weight loss in obese humans. We hypothesized that similar variations i...

Normal and streptozotocin-diabetic rats were fed a low carbohydrate diet or one of two high carbohydrate diets (sucrose or starch-bran). High carbohydrate diets were associated with slightly higher plasma glucose levels in both control and diabetic rats. However, glucose tolerance tests were not altered by the diets in either the control or diabetic rats. Plasma and liver triglyceride values fo...

We tested the hypothesis that daily aerobic exercise opposes the fasting hypertriglyceridemia and exaggerated postprandial lipemia observed after substituting dietary fat with carbohydrate. Eight healthy postmenopausal women aged 51 to 66 years consumed the same high-fat mixed meal on 3 occasions: (1) after 3 days on a low-carbohydrate diet (35%, 50%, and 15% energy from carbohydrate, fat, and ...

BACKGROUND Low-carbohydrate diets, due to their potent antihyperglycemic effect, are an intuitively attractive approach to the management of obese patients with type 2 diabetes. We previously reported that a 20% carbohydrate diet was significantly superior to a 55-60% carbohydrate diet with regard to bodyweight and glycemic control in 2 groups of obese diabetes patients observed closely over 6 ...

We investigated long-term effects of low carbohydrate diets on wild type mice, streptozotocin-injected and KKAy obese diabetic mice. These mice were pair-fed three different types of diets, standard chow (SC, C∶P∶F = 63∶15∶22), a low carbohydrate (LC, C∶P∶F = 38∶25∶37) diet and a severely carbohydrate restricted (SR, C∶P∶F = 18∶45∶37) diet for 16 weeks. Despite comparable body weights and serum...

background: premenstrual syndrome (pms) is one of the most common disorders in women in reproductive age. the study aimed to assess the effect of carbohydrate-rich supplements and diets on premenstrual syndrome. methods: the study was conducted within two stages. first stage was descriptive cross sectional investigation to find out frequency and subjects diagnosed as pms according to the apa cr...

BACKGROUND Low-carbohydrate weight-loss diets remain popular; however, the long-term effects of these diets are not known. OBJECTIVE The objective was to examine the association between low-carbohydrate-diet score and risk of type 2 diabetes DESIGN We prospectively examined the association between low-carbohydrate-diet score (based on percentage of energy as carbohydrate, fat, and protein) ...

Most fad diets are just that — a bright flash that quickly fades, only to be followed by another bestseller and a new face on the talk-show circuit. The high-fat, high-protein, low-carbohydrate (HPLC) diet has outlived the rest of the pack. This diet clearly has its supporters. In many ways, it is attractive to believe that manipulation of macronutrient composition might control body weight and...

BACKGROUND Prior research suggested that energy balance and fat intake influence prostate cancer progression, but the influence of dietary carbohydrate on prostate cancer progression has not been well characterized. We hypothesized that hyperinsulinemia resulting from high intake of refined carbohydrates would lead to more rapid growth of tumors in the murine LNCaP xenograft model of prostate c...