To assess the relative importance of the level of blood pressure (BP) and renin profile status as determinants of hypertensive left ventricular hypertrophy (LVH) and dysfunction, we studied, by quantitative echocardiography, 118 hypertensive patients off medication. The 19 high-renin patients were younger (31 +/- 13 years; p less than 0.01) but had hypertension of severity (152 +/- 13/95 +/- 11...

FUKUCHI, S., TAKENOUCHI, T. and NAIKAJTSA, K. Effect of Furosemide Administration and Upright Position on Plasma Renin Activity and Angootensin ‡U in Hypertension. Tohoku J. exp. Med., 1973, 111 (1), 71-78 Both plasma renin activity and angiotensin ‡U during recumbency measured by radioimmuno assay, were normal in essential hypertension, chronic glomerulonephritis and bilateral renal artery ste...

BACKGROUND Angiotensin II-induced hypertension is associated with increased vascular superoxide production, which contributes to hypertension caused by the octapeptide. In cell culture, stretch increases endothelial and vascular smooth muscle production of reactive oxygen species (ROS). In perfused isolated vessels, elevations of pressure can increase vessel angiotensin II production. The effec...

This review summarizes our bioassay methods for determining the level of humoral sodium pump inhibiting factor after acute volume expansion in experimental animals and humans, and in low renin experimental and human essential hypertension. In brief, ouabain-sensitive 86Rb uptake and membrane potential in blood vessels from normal animals are measured after incubation in plasma supernate from ex...

1. Plasma catecholamines and adrenergic correlates of cardiac function were compared in young men with borderline hypetension, classified according to renin status (group 1). Plasma catecholamines were increased and cardiac pre-ejection periods were shortened in 'high'-renin patients. 2. Plasma catecholamines were raised in 70% of 'high'-renin patients with primary hypertension (group 2), were ...