The effect of growth temperature on the virulence of a strain of broth-grown serogroup 1 Legionella pneumophila (Wadsworth F889) was examined by growing the bacterium at different temperatures and then infecting guinea pigs (by intratracheal injection) and guinea pig alveolar macrophages. The 50% lethal dose for guinea pigs infected with 25 degrees C-grown F889 was log10 5.0 CFU and that for 41...

Previous analyses of the Earth’s annual cycle and its trends have utilized surface temperature data sets. Here we introduce a new analysis of the global and hemispheric annual cycle using a satellite remote sensing derived data set during the period 1979–2009, as determined from the lower tropospheric (LT) channel of the MSU satellite. While the surface annual cycle is tied directly to the heat...

M-81, a new water-soluble basic peptide antibiotic, was isolated from the culture filtrate of Streptomyces griseus subsp. psychrophilus AKU 2881, which produces cryomycin only at low temperatures. M-81 was produced at 20-37°C, but not below 20 C. M-81 was active against some Gram-positive bacteria. Its antimicrobial spectrum is more limited than those of cryomycin. It darkens at 208°-213°C with...

HE SURVIVAL value of a genetic factor is conditioned by its phenotypic Tmanifestation in all environments encountered by the species, as well as by its performance in combination with the rest of the genotype of the species. The hereditary norm of reaction can be analyzed by observing a given factor under various environmental conditions and in different genotypes. DOBZHANSKY and SPASSKY (1944)...

One hundred and twenty-one sensitive (ts) sex-linked lethals were screened by means of X-ray-induced somatic crossing over to determine if any were ts cell-lethal mutants. Cell-lethal mutations were identified by their ability to block the development of homozygous clones when raised under restrictive conditions (29degrees). Twenty-two ts cell-lethal mutants were isolated and categorized into t...

Congenital fistulas of the lip are commonly found in the lower lip and accompany cleft lip. They are seen as a symptom of Van der Woude syndrome, which is predominantly hereditary. In contrast, congenital fistulas of the upper lip are rare. A number of hypotheses have been proposed to explain the pathogenesis of fistulas of the upper lip, including fusion failure of facial prominences and absen...