OBJECTIVE Despite recent advances in imaging and core or endoscopic biopsies, a percentage of patients have a major lung resection without diagnosis. We aimed to assess the feasibility of a rapid tissue preparation/analysis to discriminate cancerous from non-cancerous lung tissue. METHODS Fresh sample preparations were analyzed with the Microflex LTTM MALDI-TOF analyzer. Each main reference s...

BACKGROUND Intense ultrasound, such as that used for tumor ablation, does not differentiate between cancerous and normal cells. A method combining ultrasound and biocompatible gold or magnetic nanoparticles (NPs) was developed under in vitro conditions using human breast and lung epithelial cells, which causes ultrasound to preferentially destroy cancerous cells. RESULTS Co-cultures of BEAS-2...

THIS STUDY WAS AIMED AT: (i) investigating the expression profiles of some antioxidant and epidermal growth factor receptor genes in cancerous and unaffected tissues of patients undergoing lung resection for non-small cell lung cancer (NSCLC) (cross-sectional phase), (ii) evaluating if gene expression levels at the time of surgery may be associated to patients' survival (prospective phase). Ant...

BACKGROUND S100A7 is a secreted protein and its overexpression has been previously associated with carcinogenesis of certain cancers. This study was undertaken to investigate the possibility that overexpression of S100A7 protein might be detected in the sera of patients with lung cancer. METHODS RNA and protein levels of S100A7 were examined in 60 pairs of frozen lung cancer tissues by RT-PCR...

background: lung cancer ranks among the most common and most lethal malignancies worldwide. once vascular or lymphatic invasions occur, metastatic dissemination to distant sites is common. bone, liver, adrenals, and brain are the most frequent sites of the distant disease. in this study we present a case of squamous cell carcinoma of lung with metastasis of the left knee bursa.case presentation...

Caveolin-1 (cav-1) has been implicated in the development of human cancers. However, the distribution of cav-1 in non-small cell lung cancer (NSCLC) and its significance require further study. Real-time PCR and Western blot assays were performed to detect cav-1 mRNA and protein levels in tumor tissues (TT) and matched tumor-free tissues (TF). The protein expression in 115 paraffin-embedded block...

background: cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (nsclc). many novel drugs, including gemcitabine, vinorelbine, paclitaxel and docetaxel have been used in combination with cisplatin in this setting. of these drugs, gemcitabine is reported to have a high response rate and acceptable toxicity. the aim of this study was to evaluate the effi...

ABSTRACTIntroduction: Cancer is caused by genetic abnormalities, such as mutation of ontogenesis or tumor suppressor genes which alter downstream signaling pathways and protein-protein interactions. Comparison of protein interactions in cancerous and normal cells can be of help in mechanisms of disease diagnoses and treatments. Methods: We constructed protein interaction networks of cancerous a...

The objectives of this study are to investigate the cytotoxic effect different Citrullus colocynthis extracts on breast and lung cancer cell lines using flow cytometry gain mechanistic insights. C. was extracted sequentially Soxhlet method. We first tested plant extracts’ cytotoxicity non-malignant L929 cells cancerous (MCF-7) (A549) lines. observed that IC50 methanol extract viability MCF-7 A5...