Pulmonary and cutaneous oxygen uptake (MO2) and lung ventilation were measured in frogs floating in water with access to air in respirometers, with and without ventilation of the skin provided by stirring. The frogs were exposed to hypoxia in both water and air, and were variably active. In inactive frogs floating in unstirred respirometers at 25 degrees C, 23% of total MO2 is through the skin....

Modern techniques to isolate the lungs, coupled with accurate continuous non-invasive monitoring, have made single-lung ventilation safe and easy to perform. Most patients maintain an adequate arterial oxygen tension during single-lung ventilation. In order to maximize oxygenation, efforts are directed towards optimizing perfusion and ventilation to the ventilated lung or increasing the oxygen ...

BACKGROUND Positive-pressure mechanical ventilation is essential in assisting patients with respiratory failure in the intensive care unit and facilitating oxygenation in the operating room. However, it was also recognized as a primary factor leading to hospital-acquired pulmonary dysfunction, in which pulmonary oxidative stress and lung inflammation had been known to play important roles. Cu/Z...

One-lung ventilation is used during a variety of surgical procedures, even in patients with pre-existing coronary artery disease. The study purpose was to elucidate if myocardial metabolism crosses the anaerobic threshold under hypoxemia during one-lung ventilation. Therefore, we determined myocardial metabolism as a marker for anaerobic myocardial metabolism in patients with significant multi-...

background: maximal volume oxygen is an accepted standard for measuring cardiorespiratory readiness. this factor indicates the power of physiological adoption for increasing activity time and efficiency of cardiovascular system. the objective of this study was to find out an optimal correlation between maximal volume oxygen and maximal voluntary ventilation indicators and their effect on cardio...

Pulmonary embolism (PE) is a preventable cause of morbidity and mortality which needs prompt recognition. Ventilation-perfusion (V/Q) scan is a well-established diagnostic test for evaluation of suspected PE. We report a 32-year-old woman with history of rheumatologic disease and acute dyspnea, who was referred for V/Q scintigraphy. The planar images revealed multiple mismatched defects through...

OBJECTIVES Biologically variable ventilation improves lung function in acute respiratory distress models. If enhanced recruitment is responsible for these results, then biologically variable ventilation might promote distribution of exogenous surfactant to nonaerated areas. Our objectives were to confirm model predictions of enhanced recruitment with biologically variable ventilation using comp...

OBJECTIVE To compare the effects of high-frequency oscillatory ventilation and conventional protective mechanical ventilation associated with the prone position on oxygenation, histology and pulmonary oxidative damage in an experimental model of acute lung injury. METHODS Forty-five rabbits with tracheostomy and vascular access were underwent mechanical ventilation. Acute lung injury was indu...

Differential lung ventilation to achieve optimised ventilation for each lung is a procedure rarely used in the intensive care unit, to treat select cases of severe unilateral lung disease in intensive care. However, existing techniques both for securing the airway and ventilating the lungs are challenging and have complications. We present the use of differential lung ventilation in the intensi...

OBJECTIVE To evaluate whether ventilation strategies that target alveolar stabilization and prevention of atelectrauma would be associated with more favorable physiologic outcomes in a combined model of acute lung injury. METHODS Thirty-nine rabbits were instrumented and ventilated with FiO(2) of 1.0. Combined lung injury was induced by an infusion of lipopolysaccharide and tracheal saline la...