PURPOSE Mitochondrial disease (MD) and Duchenne muscular dystrophy (DMD) are often associated with cardiomyopathy, but the myocardial variability has not been isolated to a specific characteristic. We evaluated the left ventricular (LV) mass by echocardiography to identify the general distribution and functional changes of the myocardium in patients with MD or DMD. METHODS We retrospectively ...

CONTEXT Increased baseline left ventricular (LV) mass predicts cardiovascular (CV) complications of hypertension, but the relation between lower LV mass and outcome during treatment for hypertension is uncertain. OBJECTIVE To determine whether reduction of LV mass during antihypertensive treatment modifies risk of major CV events independent of blood pressure change. DESIGN, SETTING, AND PA...

OBJECTIVE To investigate relative contributions of glucose status and arterial stiffness to markers of left ventricular (LV) systolic and diastolic dysfunction after 8 years of follow-up. RESEARCH DESIGN AND METHODS In the population-based prospective Hoorn Study, 394 individuals with preserved LV systolic and diastolic function participated, of whom 87 had impaired glucose metabolism and 128...

We hypothesized that increased aortic forward pressure wave amplitude (Pf), which is determined by characteristic impedance (Zc) in the proximal aorta, is the primary hemodynamic determinant of obesity-associated higher left ventricular (LV) mass in adolescents. Aortic pulsatile hemodynamics were measured noninvasively in 60 healthy adolescents (age 14-19 years; 42% male; 50% black) by sequenti...

AIMS To examine relationships between cardiac troponin T (cTnT) and parameters of left ventricular (LV) structure and function in patients with acute destabilized heart failure (HF) with preserved LV ejection fraction. METHODS AND RESULTS In 44 patients with acute heart failure (HF) with preserved left ventricular (LV) ejection fraction, parameters of LV structure and function were assessed v...

Background Remodeling of the left ventricle (LV) occurs in response to various physiological and pathophysiological conditions. The American Society of Echocardiography recommend that LV remodeling be described as the relationship between LV mass and LV wall thickness based on 1-D and 2-D measurements. Cardiac magnetic resonance (CMR) provides accurate 3-D measures of LV volumes and mass; howev...

Experimental studies have implicated telomere dynamics in cardiomyocyte size and replication potential; shorter telomeres mark attenuated proliferation and increased apoptosis. The authors examined whether this translates into an impact of telomere length (TL) on left ventricular (LV) mass in the general population. In 334 randomly selected Flemish participants (mean age = 46.5 years; 52.5% wom...

Hypertension occurs in at least 70% of people with chronic kidney disease (CKD), which is estimated to affect 11% (19.2 million) of the US adult population; CKD is associated with a large and disproportionate burden of cardiovascular morbidity and mortality. CKD rivals diabetes mellitus as a coronary risk equivalent in veterans. Established risk factors for cardiovascular disease include left v...

Childhood obesity has increased dramatically in the United States during the past 30 years, which has been associated with a parallel rise in systolic blood pressure (BP) and pulse pressure (PP) in adolescents and young adults. Consistent with the elevation in systolic BP and PP, there has been an increase in the rates of prehypertension and hypertension mostly in youth with obesity, with the m...

Context Catecholamines may contribute to the accumulation of collagen fibers and extracellular matrix in the arterial and myocardial wall due to various mechanisms. Reversibility of this process has not been studied on both structures simultaneously. Objective To clarify the long-term effect of excess normalization of catecholamines on carotid and myocardial wall changes in patients with pheo...