نتایج جستجو برای: lymphocytic leukemia
تعداد نتایج: 291188 فیلتر نتایج به سال:
Lenalidomide is an immunomodulatory agent clinically active in chronic lymphocytic leukemia patients. The specific mechanism of action is still undefined, but includes modulation of the microenvironment. In chronic lymphocytic leukemia patients, nurse-like cells differentiate from CD14(+) mononuclear cells and protect chronic lymphocytic leukemia cells from apoptosis. Nurse-like cells resemble ...
Ecthyma Gangrenosum is a severe skin disease commonly associated with Pseudomonas aeruginosa septicemia, there an increased risk of infection in patients malignancy undergoing chemotherapy notably Chronic lymphocytic leukemia (CLL). We present case report CLL patient infested by P. aeruginosa.
BACKGROUND The somatic genetic basis of chronic lymphocytic leukemia, a common and clinically heterogeneous leukemia occurring in adults, remains poorly understood. METHODS We obtained DNA samples from leukemia cells in 91 patients with chronic lymphocytic leukemia and performed massively parallel sequencing of 88 whole exomes and whole genomes, together with sequencing of matched germline DN...
BACKGROUND The concept of "accelerated" chronic lymphocytic leukemia is frequently used by both pathologists and clinicians. However, neither histological criteria to define this form of chronic lymphocytic leukemia nor its clinical correlates and prognostic impact have been formally defined in large series of patients. DESIGN AND METHODS Tissue biopsies from 100 patients with chronic lymphoc...
PURPOSE To compare the characteristics of tubercular vs. leukemic involvement of abdominopelvic lymph nodes using multidetector computed tomography (CT). MATERIALS AND METHODS We retrospectively reviewed multidetector computed tomography features including lymph node size, shape, enhancement patterns, and anatomical distribution, in 106 consecutive patients with newly diagnosed, untreated tub...
BACKGROUND The nucleoside analogue fludarabine is used in the treatment of chronic lymphocytic leukemia. It triggers p53-mediated apoptosis, although the mutational status of p53 does not fully account for heterogeneity in responsiveness to treatment. The aim of this study was to identify new genes implicated in fludarabine action as well as to determine the role of equilibrative nucleoside tra...
Luekemic infiltration of the prostate is unusual. Acute urinary retention as an initial presentation of chronic lymphocytic leukemia is found only in sporadic cases. Organ confmed adenocarcinoma of prostate associated with chronic lymphocytic leukemia and presenting as acute urinary retention is to our knowledge not reported in literature. This report documents a case of acute urinary retention...
BACKGROUND Chronic lymphocytic leukemia is a neoplastic disorder that arises largely as a result of defective apoptosis leading to chemoresistance. Stromal cell-derived factor-1 and its receptor, CXCR4, have been shown to play an important role in chronic lymphocytic leukemia cell trafficking and survival. DESIGN AND METHODS Since histone acetylation is involved in the modulation of gene expr...
BACKGROUND In the 2008 World Health Organization classification, small lymphocytic lymphoma is defined as a neoplasm with the tissue morphology and immunophenotype of chronic lymphocytic leukemia, but with absence of leukemia. Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined. DESIGN AND METHODS We reviewed...
s from 719 unique publications were screened. 502 articles were excluded: • 23 articles were not in English. • 85 articles were not conducted in humans. • 99 articles were reviews/editorials. • 295 articles investigated irrelevant phenotypes or risk factors. Figure 1. Numbers of published articles retrieved for and excluded from an assessment of candidate-gene association studies of chronic lym...
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