نتایج جستجو برای: macrolides

تعداد نتایج: 4269  

2018
Frederik Boetius Hertz Aksel Jensen Jenny D Knudsen Magnus Arpi Charlotte Andersson Gunnar H Gislason Lars Køber Christian Torp–Pedersen Freddy Lippert Peter E Weeke

INTRODUCTION AND OBJECTIVES Macrolides have been associated with proarrhythmic properties, but the evidence is conflicting. We evaluated the risk of out-of-hospital cardiac arrest (OHCA) associated with specific macrolides in a retrospective study. Associations between specific macrolides and OHCA were examined by conditional logistic regression analyses in case-crossover and case-time-control ...

2004
P. Wijkstra

study are relevant, I believe that the design of the study was not adequate to answer these questions. First, all patients were on NM for w3 months and one patient even for 70 months, whereas they trained only for 1 day on FFM. In our centre (Dept of Pulmonary Diseases/ Home mechanical ventilation, University Hospital Groningen, Groningen, The Netherlands), patients routinely need more time (y7...

Journal: :Internal medicine 1995
T Shirai A Sato K Chida

We studied the efficacy of the long-term administration of 14-membered ring macrolides in treating patients with diffuse panbronchiolitis (DPB) (34 patients) and bronchiectasis (BE) (40 patients). Oral administration of erythromycin (400 or 600 mg), roxithromycin (150 or 300 mg) or clarithromycin (200 or 400 mg) given daily for at least 2 months, was evaluated. The efficacy of erythromycin, rox...

Journal: :The Journal of antimicrobial chemotherapy 1996
M Viluksela P J Vainio R K Tuominen

Cytotoxicity of erythromycin base, erythromycin estolate, erythromycin-11,12-cyclic carbonate, roxithromycin, clarithromycin and azithromycin was compared in cultured human non-malignant Chang liver cells using reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide and cellular protein concentration as end points of toxicity. Erythromycin estolate was the most toxic macrolid...

Journal: :Clinical microbiology reviews 2010
Soichiro Kanoh Bruce K Rubin

Macrolides have diverse biological activities and an ability to modulate inflammation and immunity in eukaryotes without affecting homeostatic immunity. These properties have led to their long-term use in treating neutrophil-dominated inflammation in diffuse panbronchiolitis, bronchiectasis, rhinosinusitis, and cystic fibrosis. These immunomodulatory activities appear to be polymodal, but evide...

Journal: :Antimicrobial Agents and Chemotherapy 2013

Journal: :Clinical Microbiology and Infection 2006

Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1998
C Carbon

The efficacy of macrolides against extracellular pathogens depends on extracellular levels of free drug and the organisms' patterns of susceptibility to the macrolides. The effect of macrolides against most bacteria is considered time-dependent. The size of inoculum affects erythromycin's activity against streptococci and, moreover, against staphylococci. The optimal effect is observed at a pH ...

Journal: :The European respiratory journal 1997
O Culić V Eraković M J Parnham

Macrolides are widely used as antibacterial drugs. Clinical and experimental data, however, indicate that they also modulate inflammatory responses, both contributing to the treatment of infective diseases and opening new opportunities for the therapy of other inflammatory conditions. Considerable evidence, mainly from in vitro studies, suggests that leukocytes and neutrophils in particular, ar...

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