Low potassium and magnesium status and decreased Na, K-pump activity is an endemic condition among rural Northeast Thais. The authors examined the effect of supplementing potassium and magnesium on erythrocyte potassium, sodium and magnesium content and on Na, K-pump activity. Rural Northeast Thai renal stone patients (62) were recruited, divided into four groups and supplemented for one month ...

OBJECTIVE A study with human volunteers was conducted to ascertain whether a low intake of copper (Cu) would exacerbate the response to a deficient intake of magnesium (Mg). METHODS Nineteen postmenopausal women, age 47 to 78 y, completed a metabolic unit study as designed. For 162 d, nine women were fed a diet containing 1.0 mg of Cu/2000 kcal and 10 women were fed 3.0 mg of Cu/2000 kcal. Di...

Although much is known about magnesium, its interactions with calcium and vitamin D are less well studied. Magnesium intake is low in populations who consume modern processed-food diets. Low magnesium intake is associated with chronic diseases of global concern [e.g., cardiovascular disease (CVD), type 2 diabetes, metabolic syndrome, and skeletal disorders], as is low vitamin D status. No simpl...

Whereas in the general population magnesium deficits are most often thought to result mainly in calf cramps (which are generally not considered to be life threatening), it is less well known that a magnesium deficit induced by a magnesium-deficient diet in humans resulted in severe cardiac arrhythmias [5] . Other studies as, for example, an epidemiological study in Germany showed that low serum...

Magnesium tolerance tests were conducted in five female goats to determine the effect of increasing dietary potassium level from .9% (basal diet) to 4.0% (high-K diet) on an animal's capacity for disposing of an intravenous load of magnesium. Both diets contained about .07% magnesium, .91% calcium and .56% phosphorus. Following intravenous injections of magnesium acetate (.5 mEq of Mg/kg body w...

Magnesium levels in serum, erythrocytes, skeletal muscle, and bone were measured in 10 patients with valvular heart disease who had received diuretic therapy for heart failure for an average of 3.3 years. Five patients were found to have diminished values for skeletal muscle, indicating significant magnesium deficit. Values for erythrocytes were low in only two of the five patients, and none ha...

background : magnesium is the second most abundant intracellular cation. it plays an important role in insulin homeostasis and glucose metabolism through multiple enzymatic reactions. with increasing data on magnesium deficiency in diabetic patients and epidemiological studies demonstrating magnesium deficiency as a risk factor for diabetes, it is logical to search for its possible beneficial e...

BACKGROUND Rest cramps (also known as nocturnal leg cramps) are very common in a geriatric population. Oral magnesium supplements are marketed for prophylaxis of such cramps but clinical trials exploring the efficacy of oral magnesium conflict. A therapeutic trial of intravenous magnesium overcomes the limited oral bioavailability of magnesium and better assesses its therapeutic potential. ME...

When extracellular magnesium is reduced by a factor of 50 (from 1.0 to 0.02 mM), the total intracellular magnesium of a spontaneously transformed clone of 3T3 cells decreases by 30-50%. Protein synthesis rates in these cells were measured as the intracellular magnesium decreased. Protein synthesis rates and magnesium content were found to decrease in parallel with each other. At 3 hr, a decreas...

Determination of magnesium in mononuclear blood cells may provide useful information about intracellular magnesium. Mononuclear blood cell preparations are frequently contaminated with granulocytes. We determined the normal reference interval for magnesium content and concentration of granulocytes and compared it with magnesium in mononuclear blood cells. The mean granulocyte magnesium concentr...