Malaria remains a health and economic burden, particularly in marginalized populations worldwide. The current strategies for combating malaria rely on eliminating the mosquito vector, using insecticide-treated nets, other management policies or through administration of small molecule drugs to perturb intra-erythrocytic development parasite. However, resistance against commonly used such as art...

Malaria is a disease caused by repeated cycles of growth of the parasite Plasmodium in the erythrocyte. Various cellular and molecular strategies allow the parasite to evade the human immune response for many cycles of parasite multiplication. Under certain circumstances Plasmodium infection causes severe anemia or cerebral malaria; the expression of disease is influenced by both parasite and h...

BACKGROUND This study was to assess malaria prevalence in relation to rainfall pattern in different localities of Entebbe Municipality, Uganda. A cross sectional study was conducted amongst the local community residing in the area from January 2003 to January 2004 to investigate the incidence and intensity of malaria infection. METHODS Thick and thin blood smears were made from each patient w...

Malaria is one of the most devastating diseases prevalent in the world. It is caused by the parasite Plasmodium falciparum. Many species of Plasmodium are shown to infect human host. The increased resistant in malaria parasite against drugs remain the major concern. Hence identification of new and effective drug targets against Plasmodium is a regular process. In the same line, proteases are th...

Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...

Goniothalamin was evaluated for its anti-malaria activity in-vivo, using the 4-Day Suppressive Test (Peters & Robinson, 1975). The test were carried out against two strains of rodent malaria parasites, the sensitive strain P. berghei ANKA (MRA 311) strain and the resistant strain P. yoelii (MRA 312). An Initial screening was carried out using a single dose of 10 mg/kg body weight administered s...

BACKGROUND Whole malaria parasites are highly effective in inducing immunity against malaria. Due to the limited success of subunit based vaccines in clinical studies, there has been a renewed interest in whole parasite-based malaria vaccines. Apart from attenuated sporozoites, there have also been efforts to use live asexual stage parasites as vaccine immunogens. METHODOLOGY AND RESULTS We u...

Erhabor et al1 describe the prevalence of asymptomatic malaria in a unique study population of truck drivers, who have otherwise featured in medical literature for risky sexual behaviour and associated high HIV prevalence rates2. Their findings suggest that limited access to adequate health care facilities and preventative strategies exposes truck drivers to infection with plasmodium facliparum...