3 PharmaEast GmbH, Berlin, Germany There is increasing evidence indicating that certain drugs evoke adverse drug effects that depend on the gender of patients. Elucidation of gender-effect of various drugs by means of preclinical trials is an important field of pharmacology. The chloriuretic and natriuretic effect of valproates (VPA) had not been investigated earlier, so the aim of the present ...

Aim: The current study investigated the anti-oxidant effects of vitamins on lead-induced reproductive toxicity in male wistar rats.
 Study Design: A total 48 Wistar rats divided into 6 groups 8 per group were used this study. Group 1 served as positive control and was given normal animal feed water ad libitum. 2 negative administered 10mg/kg body weight lead acetate (Pb) only, 3 with 200mg...

correspondence: Erhabor Osaro Blood sciences Department, Royal Bolton hospital, Bolton Lancashire, UK Tel +44 79 3236 3217 Email [email protected] Abstract: This study was carried out to investigate the effect of prolonged intake of calciumchannel blocker amlodipine, an antihypertensive drug on gonadal steroid hormone (testosterone) of male albino rats. Three different concentrations of amlodip...

This study was carried out to investigate the effect of prolonged intake of calcium-channel blocker amlodipine, an antihypertensive drug on gonadal steroid hormone (testosterone) of male albino rats. Three different concentrations of amlodipine (0.01, 0.02 and 0.03 mg/kg body weight) was administered orally to three different groups (B, C, and D) of experimental male Wistar albino rats (n = 8) ...

introduction: wistar rats are an outbred strain of albino rats belonging to the species rattus norvegicus. histopathological studies on the testis was carried out to determine the effects of heat and lead on male fertility by evaluating some andrological parameters of the wistar rat such as morphology of spermatozoa, sperm count and motility. the main objective of this research was to compare t...

(NTS) in Wistar rats (WR) and spontaneously hypertensive rats (SHR), our previous results suggested that sustained hypertension might aggravate the nephrotoxic processes or protract the course of glomerulonephritis. The present study was attemped to observe the more prolonged glomerular changes of nephrotoxic nephritis (NTN) until 15 weeks after the injection of NTS in SHR, compared with contro...

The current Western diet contains high amounts of salt and fat. High fat diets are known to have negative impacts on food intake (FI), body weight (BW), composition (BC), glucose metabolism, blood pressure. These factors been studied as separate entities, but the main interactive effects dietary received little study. objective this study was examine effect sodium content FI, BW, BC in male Wis...

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids can lower decrease thickening. To determine the effect of bay (Syzygiumpolyanthum) on ventricle thickening rat (Rattus norvegicus wistar strain) in hypertensive model. T...

The study was to evaluate the neurobehavioural and cognitive changes in Wistar rats administered carbamazepine (CBZ), phenytoin (PHE) and their combination. Forty, apparently, healthy adult male Wistar rats weighing about 300 g were divided into four groups of 10 animals each. Group I rats were administered distilled water at 10 ml/kg. CBZ, 20 mg/kg, PHE 100 mg/kg and CBZ+PHE, 20 mg/kg and 100 ...