A nine year-old male had refractory seizures for four years. Diagnostic imaging (Fig 1A and B) demonstrated a cortico-subcortical focal lesion at the isthmus of the right cingulate gyrus. Biopsy yielded diagnosis of ganglioglioma (Fig 2A). Reoperation one year later showed similar features, but included atypical and multinucleated cells (Fig 2B). At the age of 13, the patient had symptom recurr...

Giant congenital melanocytic nevi (GCMN) are rare skin lesions that affect approximately 1 in 20,000 live births. GCMN must be followed up closely because of its association with an increased risk malignant degeneration. We report a newborn giant lession 14 cm diameter which was located on the chest and multiple satellite were present body. The patient required phototherapy due to hyperbilirubi...

We present an unusual case of a melanocytoma of the optic disc that showed documented progressive growth over a period of six years. It reached the largest size of any reported optic nerve melanocytoma and the eye was enucleated because of the possibility of malignant degeneration. Optic nerve melanocytomas are locally invasive but are not known to undergo transformation into malignant melanoma...

The degeneration of chronic wounds into basal cell carcinoma is rare. We present an atypical case of basal cell carcinoma diagnosed by soft tissue biopsy in a long-standing wound that had been treated for 3 years as a chronic venous stasis ulcer. In addition to the case report, we review the biomedical literature describing malignant transformation of long-standing wounds. Foot and ankle specia...

Although rare, malignant melanoma occurs in children. The risk of degeneration of a congenital melanocytic nevus into a melanoma is approximately 0.7%. We report a case of malignant melanoma that developed on a congenital melanocytic nevus in a 19-month-old boy. The child was treated by surgical resection, superficial parotidectomy, and modified radical neck dissection with adjuvant therapy. Th...

INTRODUCTION Bronchogenic cysts may rupture or become infected, and malignant degeneration may occur. Although various types of malignant degeneration have been described, only a few reports of mucoepidermoid carcinoma arising from a bronchogenic cyst have been published. We report such a case. CASE A 77-year-old female was referred to our institution for evaluation of left chest pain. A comp...

INTRODUCTION We report an unusual case of a large cystic, pedunculated uterine leiomyoma mimicking a primary malignant ovarian tumour on sonography and computed tomography (CT). CLINICAL PICTURE A 56-year-old post-menopausal woman presented with a right pelviabdominal mass. Sonography and CT examination showed a large extrauterine mass arising from the right adnexa and extending into the abdo...

BACKGROUND Retrorectal hamartoma, also known as tailgut cyst, is a rare tumor that arises from remnants of the embryonic postanal gut. The tumor occurs in the retrorectal space and may undergo malignant degeneration. METHODS The clinical information on a single patient with pseudomyxoma peritonei associated with a tailgut cyst was reviewed and a literature review of the subject performed. R...