proper differentiation between acral malignant melanoma and benign pigmented lesions like melanocytic nevi is of great value. to avoid unnecessary biopsies, dermatoscopy has been introduced as a non-invasive modality and has improved the clinical diagnostic accuracy in recent decades. we aimed to describe dermoscopic patterns of acral pigmented lesions of patients in the clinic of dermatology i...

epidemiology studies have demonstrated inconsistent associations between type 2 diabetes mellitus and the risk of malignant melanoma. to this end, the aim was to perform a meta-analysis of cohort studies.medline, pubmed, embase and the cochrane library were searched up to february 2014. cohort studies addressing the relative risk of type 2 diabetes mellitus on malignant melanoma were included i...

purpose: true neoplasm (adenocarcinoma) of retinal pigment epithelium (rpe) is very rare since it can be misdiagnosed as intraocular malignant melanoma it is of importance to know the clinical and pathologic aspects of this neoplasm. here, we report a case of adenocarcinoma of rpe. methods: case report. results: a 60-year-old man with progressive loss of the vision of the right eye was enucleat...

Synonyms: Clear cell sarcoma of soft tissue, Clear cell sarcoma of the tendons and aponeuroses, malignant melanoma of the soft parts. Background: Rodriguez-Martin, Ortiz-Cruz, Del Rio, Vivanco, & Lopaz-Amor in 2011 stated “Clear cell sarcoma is a high-grade soft tissue sarcoma seen in adolescents and young adults, with melanosytic differentiation typically involving tendons and aponeuroses”. Cl...

Clear cell sarcoma (CCS, malignant melanoma of soft parts) is a rare neoplasm accounting for 1% of all soft tissue sarcomas (1). Young adults between the ages of 20 and 40 are most commonly involved (1). CCS is intimately associated with or in a tendon, ligament, or aponeurosis. Suggestive features of diagnosis best seen on MR imaging include a mass having components not only surrounding but wi...

Clear cell sarcoma (CCS) is a rare, distinctive soft tissue neoplasm, typically occurring in the distal extremities of young adult patients. Although CCS shows melanocytic differentiation, it is now clear that it is clinicopathologically and genetically distinct from conventional malignant melanoma. The 'osteoclast-rich tumour of the gastrointestinal tract with features resembling clear cell sa...

malignant melanoma of the esophagus is a rare tumor with poor prognosis. the survival of patients is generally less than one year after diagnosis. a case of primary malignant melanoma of the esophagus is presented, who after radical resection of the tumor, is in excellent health, with no evidence of disease 14 months after surgery.

Background: Malignant melanoma is the most aggressive form of skin cancer. In contrast to other tumors, the role of estrogen in the initiation and progression of melanoma remains unclear. The aim of this study was to evaluate estrogen receptor beta protein expression in human melanoma tissues and in the benign melanocytic lesions. Method: Twenty-one patients, 11 with cutaneous melanoma and 10 w...

The nose is an uncommon site for a malignant melanoma, representing 2% to 5% of head and neck malignant melanoma. Nasal malignant melanoma develops from the melanocytes residing in mucous membranes that have migrated during embryologic development from the neural crest to the mucosa of the nose and sinuses. We report two case of the nasal septal malignant melanoma. the first case was 48-years –...

Zosteriform metastasis is a rare clinical distribution from spreading neoplasms of every organ to the skin. Tumors most often arise from a n internal o r hematologic malignancy. W e report a 69-year-old man, a known case of malignant melanoma of the left heel. In this case, multiple red-brown metastatic nodules appeared four months after diagnosis. Distribution of metastatic lesions resemb...