Ovarian germ cell tumors (OGCTs) show a heterogeneity that is not seen in their testicular counterparts and include benign mature cystic teratomas, intermediate immature teratomas, malignant germ cell tumors [GCTs (dysgerminomas, endoderma! sinus tumors, and mixed GCTs)], and GCTs arising in dysgenetic gonads of 46,XY individuals. Comparative genomic hybridization was used to analyze 27 OGCTs f...

Ovarian germ cell tumors (OGCTs) show a heterogeneity that is not seen in their testicular counterparts and include benign mature cystic teratomas, intermediate immature teratomas, malignant germ cell tumors [GCTs (dysgerminomas, endodermal sinus tumors, and mixed GCTs)], and GCTs arising in dysgenetic gonads of 46,XY individuals. Comparative genomic hybridization was used to analyze 27 OGCTs f...

Introduction: Germ cell tumors account for 3.5 % of pediatric and yolk sac are the most common pure malignant germ in children. Testis ovary sites involvement children older than 2 years. Case Presentation: A 20-month-old boy with a complaint limping was described this case report. Abdominal ultrasonography showed 52 × 50 mm solid abdominal mass. pelvic computed tomography scans left paraspinal...

Teratomas are tumors of germ cell derivation consist of tissues derived from all the three germ cell layers. They comprise the most common extragonadal germ cell tumors (EGCT) in childhood. EGCTs of head and neck region account for only 5% of all benign and malignant germ cell tumors and for 6% of all teratomas. Primitive neuroectodermal tumor (PNET) arising from germ cell tumor is a distinct e...

5 Original Publications 8 Abbreviations 9 Introduction 10 Review of the Literature 11 1. Germ cells 11 1.1 Inner cell mass and embryonic stem cells 11 1.2 Factors essential for maintenance of pluripotency and self-renewal 11 1.3 Development and migration of germ cells 14 2. Gonadal development 16 2.1 Ovarian differ entiation 17 2.2 Testicular differentiation 18 3. GATA transcription factors in ...

Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]....

Defining normal and malignant germ cell development is crucial for understanding the biology and behavior of germ cell tumors. Germ cell tumors show significant similarities with immature germ cells. Furthermore, treatment sensitivity of germ cell tumors reflects the intrinsic characteristics of the cell of origin, and their derivatives. The aim of this thesis was to identify factors involved i...

Ovarian tumors can be classified by their origin - epithelial tumors, germ cell and stromal tumors. Malignant struma ovarii (MSO) are 0.01% of all ovarian In order to as a ovarii, more than 50% the teratoma consists thyroid tissue. The tissue in exhibits same histological physiological properties that cervical Poorly differentiated carcinoma (PDTC) is an extremely rare occurrence when arising f...