marfan’s syndrome (mfs) is a genetic disorder associated with autosomal dominant inheritance. in mfs, the most prevalent cause of death is cardiovascular involvement. here we introduce a family with a severe penetration of mfs. eleven members of this family have mfs (father, two daughters, three sons, and five grandchildren). the most common cardiac involvement in our patients was mitral valve ...

Nowadays viral hepatitis is one of the most common and important causes of chronic liver disorders in the world. Extrahepatic manifestations of viral hepatitis consist a main part of the disease. The main viruses causing hepatitis include Hepatitis A, B and C viruses. Herein common skin manifestations in hepatitis C virus (HCV) are discussed. Chronic hepatitis causes skin disorders both directl...

aim : the study aims to document the oral lesions in patients with uc. background : inflammatory bowel disease (ibd) is comprised of two chronic, tissue-destructive and clinical entities including crohn's disease (cd) and ulcerative colitis (uc), both of which are immunologically based. patients and methods : the population of the study includes fifty patients with uc, as the experimental group...

ANNALS COMMENTARY ANNALS COMMENTARY intellectual commerce-legal paradigms for global initiatives Human intellect is the genesis of the proud civilizations, where it carried out its collective march towards a 'better tomorrow'. The creative manifestations of the great intellects brought all of us from dark and dingy grottos to the luminous urbanity of the present day. For every small step forwar...

The Genetic Information Nondiscrimination Act of 2008 (GINA) was passed to encourage patients to seek genetic testing that could improve health outcomes and provide opportunities for preventive measures. GINA protects individuals from discrimination based upon genetic information, but not upon manifested diseases and conditions. Because the manifestation of a disease establishes a threshold of ...

background : ulcerative colitis an inflammatory bowel disease (ibd) and chronically idiopathic immune related that associates with extraintestinal manifestations such as arthritis. despite of the highly specificity ofanti-cyclic citrullinated peptide (ccp) antibodies for rheumatoid arthritis, their role in ibd remains unclear . there are only a few studies on the prevalence of anti-ccp antibodi...

background: bladder cancer accounts for about 7% of all cancers among adults in iran. we aimed to evaluate epidemiological and clinicopathological features of bladder cancer in kermanshah province, west iran. methods: in a descriptive retrospective study, records of patients with bladder cancer referring to imam reza hospital, kermanshah city, iran during 2011-2013 were analyzed. sex, age, smok...

background: retinoblastoma is the most common embryonic tumor of retina of children. this tumor include 3-4% of all children malignancies during the age range 0-14 years. in this study, we reported the incidence, therapeutic protocols, and treatment outcome of children with rb in south west iran. methods: we retrospectively investigated the medical reports clinical and pathological features of ...

background: defects in b cell class switch recombination (csr) are a heterogeneous and yet very uncommon group of disorders which all have a genetic basis uniformly leading to hyper igm (higm) syndrome. due to the rare frequency of these conditions, a very small number of case series have been conducted on the affected patients. objective: to shed some light on the morbidity and mortality regar...