Mannich bases are the end products of Mannich reaction and are known as beta-amino ketone carrying compounds. Mannich reaction is a carbon-carbon bond forming nucleophilic addition reaction and is a key step in synthesis of a wide variety of natural products, pharmaceuticals, and so forth. Mannich reaction is important for the construction of nitrogen containing compounds. There is a number of ...

Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity m...

This paper aims to investigate the localized corrosion mechanism of Q125 casing steel in residual acid solution with Mannich base type inhibitors during oil reservoir acidizing process. The behavior fresh (20% HCl) and (pH 1.0 pH 3.0 without 3-(4-chlorophenylimino)-1-(piperidine-1-ylmethyl) indolin-2-one (Mannich type, Mb) inhibitor was studied by electrochemical test, weight loss, surface anal...

In the present investigation, a series of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-5(4H)-one analogues of pyrazole were synthesized by cyclization of mannich base with hydrazine hydrate. The nitrogen functionality of 4-(4-(dimethylamino) benzyl)-3-methyl-1Hpyrazol-5(4H)-one was alkylated with different halogenated alkylated substituted chain in the presence of base. The chemical structur...

We recently demonstrated that chiral cyclopropenimines are viable Brønsted base catalysts in enantioselective Michael and Mannich reactions. Herein, we describe a series of structure–activity relationship studies that provide an enhanced understanding of the effectiveness of certain cyclopropenimines as enantioselective Brønsted base catalysts. These studies underscore the crucial importance of...

We recently demonstrated that chiral cyclopropenimines are viable Brønsted base catalysts in enantioselective Michael and Mannich reactions. Herein, we describe a series of structure-activity relationship studies that provide an enhanced understanding of the effectiveness of certain cyclopropenimines as enantioselective Brønsted base catalysts. These studies underscore the crucial importance of...

BACKGROUND Alzheimer's disease (AD), a progressive and degenerative disorder, has become one of the severe problems among the aged population all over the world. To use cholinesterase inhibitor drugs has become the most predominant treatment strategy for AD. RESULTS A series of novel 1, 3-dihydroxyxanthone Mannich bases derivatives (1a ~ 4e) were synthesized, structure elucidated and evaluate...

Distinctions between primary and secondary are defined, and the basic building blocks used in the biosynthesis of secondary natural products are introduced. The chemistry underlying how these building blocks are assembled in nature is described, subdivided according to chemical mechanism, including alkylation reactions, Wagner–Meerwein rearrangements, aldol and Claisen reactions, Schiff base fo...