نتایج جستجو برای: map3k1
تعداد نتایج: 174 فیلتر نتایج به سال:
*Greenebaum Cancer Center, Department of Microbiology and Immunology, Molecular and Cellular Biology Program, University of Maryland School of Medicine, Baltimore, MD 21201; §Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267; ¶University of Maryland School of Pharmacy, Baltimore, MD 21201; Department of Toxicology, Johns Hopkins University School ...
IDH1-mutated cholangiocarcinomas (CCAs) are an interesting group of neoplasia with particular behavior and therapeutic implications. The aim the present work is to highlight differences characterizing IDH1m IDH1wt CCAs in terms genomic landscape. 284 patients iCCA treated for resectable, locally advanced or metastatic disease were selected studied FOUNDATION Cdx technology. A comparative analys...
MEKK1 (also known as MAP3K1), which plays a major role in MAPK signaling, has been implicated in mechanical processes in cells, such as migration. Here, we identify the actin-binding protein calponin-3 as a new MEKK1 substrate in the signaling that regulates actomyosin-based cellular contractility. MEKK1 colocalizes with calponin-3 at the actin cytoskeleton and phosphorylates it, leading to an ...
DNA sequencing of candidate genes or whole exomes on a diagnostic or investigational basis will yield a plethora of variants of uncertain significance whose potential phenotypic roles cannot be readily demonstrated by prediction programs, SNP databases nor conventional genetic analysis. Many variants may produce phenotypic changes in the encoded proteins by affecting the quantity, post-translat...
Follicular helper T cells (Tfh) have been well documented to play a critical role in autoimmunity, such as systemic lupus erythematosus (SLE), by helping B cells. In this study, high salt (sodium chloride, NaCl), under physiological conditions, was demonstrated to increase the differentiation of Tfh. A high-salt diet markedly increased lupus features in MRL/lpr mice. The mechanism is NaCl-induc...
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