In classical mechanical testing, determining the stress and strain states of complex shape specimens turns out to be very challenging, especially in most deformed regions. latter case, when not enough material is present, non-destructive testing needed for corresponding state. this study, a novel approach, based on local quasi-non-destructive instrumented indentation technique (IIT) coupled wit...

The aim of the present study was to assess the profiles of the exoglycosidases: N-acetyl-β-hexosoaminidase, β glucuronidase and β galactosidase, α mannosidase and α fucosidase in fibroblast culture undergoing replicative and stress-induced senescence. Half of the cell culture was grown in normal conditions, without the stressor, and the other half of the cell was treated with 0.15 mM tert-butyl...

We present a global stability analysis of two-compartment models of a hierarchical cell production system with a nonlinear regulatory feedback loop. The models describe cell differentiation processes with the stem cell division rate or the self-renewal fraction regulated by the number of mature cells. The two-compartment systems constitute a basic version of the multicompartment models proposed...

Modification of Airway Smooth Muscle Responses in the Guinea Pig by Hydrocortisone, in Vitro and in Vivo. Ca& Es BRINK, PAMELA RIDGWAY AND JAMES S. DOUGLAS 1 Mechanism of Isoproterenol-Induced Desensitization of Tracheal Smooth Muscle. CHIH-SHION LIN, LEON HURWITZ, JOHN JENNE AND B .iuty P. AVNER 12 Inactivation of Norepinephrine in an Isolated Vein. FERNANDO Bit NDAo 23 Histamine Mediation in ...

In this paper we investigate the limit behavior of the solution to quasi-static Biot’s equations in thin poroelastic flexural shells as the thickness of the shell tends to zero and extend the results obtained for the poroelastic plate by Marciniak-Czochra and Mikelić in [16]. We choose Terzaghi’s time corresponding to the shell thickness and obtain the strong convergence of the three-dimensiona...

α1-Antitrypsin is a serine protease inhibitor produced in the liver that is responsible for the regulation of pulmonary inflammation. The commonest pathogenic gene mutation yields Z-α1-antitrypsin, which has a propensity to self-associate forming polymers that become trapped in inclusions of endoplasmic reticulum (ER). It is unclear whether these inclusions are connected to the main ER network ...

This study analyses the effect of martensite grain size and its volume fraction in dual-phase (DP) steel on (1) formability limit, (2) average global behavior under different loading conditions, (3) damage initiation. The virtual RVEs (Representative Volume Elements) were constructed using DREAM.3D software with a variation microstructural attributes. numerical simulations carried out DAMASK, w...

BACKGROUND In this study we have investigated the effects of type I (insulin-dependent) and II (non-insulin dependent) diabetes mellitus on the specific activity and the output of salivary exoglycosidases: N-acetyl-β-hexosoaminidase (HEX), and its isoenzymes A and B (HEX A, HEX B), and β-glucuronidase (GLU) in well controlled diabetic patients compared to healthy age-matched controls. MATERIA...

AIM Colorectal cancer is characterized by high morbidity and mortality in developed countries. The lack of low-cost, easy-to-use screening diagnostic methods is one of the causes of late diagnosis of colorectal cancer. Beta-glucuronidase (GLU) is a lysosomal exoglycosidase involved in degradation of glycosaminoglycans of the cell membranes and extracellular matrix of normal and cancerous colon ...