OBJECTIVES Previous work has shown that the CO-releasing molecule CORM-2 protects against cartilage degradation. The aim of this study was to examine whether CORM-2 can control the production of inflammatory mediators in osteoarthritic chondrocytes and determine the mechanisms involved. METHODS Primary cultures of chondrocytes from OA patients were stimulated with IL-1beta. The production of ...

Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator in mammalian cells. Here we show that precise delivery of CO to isolated heart mitochondria using a water-soluble CO-releasing molecule (CORM-3) uncouples respiration. Addition of low-micromolar concentrations of CORM-3 (1-20 μM), but not an inactive compound that does ...

AIMS Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) reverses metabolic syndrome-induced cardiac alteration through changes in mitochondrial biogenesis, dynamics and autophagy. METHODS AND RESULTS Mice were fed...

introduction saffron as a food, spicy and medicinal plant has more than 62000 ha under cultivation with about 250 tons annual dry stigma production in iran, which includes about 90% of its world production. therefore, this plant has a specific value in agricultural export products of iran (fallahi et al., 2014). due to the important role of saffron in iran’s agroecosystems, the improvement of i...

OBJECTIVE Damage to intestinal epithelial tight junctions plays an important role in sepsis. Recently we found that Carbon Monoxide-Releasing Molecule-2 (CORM-2) is able to protect LPS-induced intestinal epithelial tight junction damage and in this study we will investigate if CORM-2 could protect intestinal epithelial tight junctions in the rat cecal ligation and puncture (CLP) model. MATERI...

In Crocus vernus, a spring bulbous species, prolonged growth at low temperatures results in the development of larger perennial organs and delayed foliar senescence. Because corm growth is known to stop before the first visual sign of leaf senescence, it is clear that factors other than leaf duration alone determine final corm size. The aim of this study was to determine whether reduced growth ...

a prospective study of 550 consecutive mothers delivered in amin ob. gyn center of isfahan university was performed to determine the relationships between maternal anemia, placental weight and neonatal birth weight. the important findings were marked placental hypertrophy in anemic mothers. (r= -/9.95) .it is probable that in anemic mothers placental hypertrophy is a compensatory mechanism resp...

introduction: there is a great deal of controversy regarding the effect of gestational magnesium (mg) deficiency on fetal growth and the incidence of low birth weight (lbw) in infants. therefore, this study aimed to delineate the possible relationship between maternal mg level and infant lbw. methods: this case-control study was conducted on 180 mothers in shiraz, iran. fasting blood samples we...

BACKGROUND Hepatic ischemia-reperfusion injury (I/Ri) is a serious complication occurring during liver surgery that may lead to liver failure. Hepatic I/Ri induces formation of reactive oxygen species, hepatocyte apoptosis, and release of pro-inflammatory cytokines, which together causes liver damage and organ dysfunction. A potential strategy to alleviate hepatic I/Ri is to exploit the potent ...