The current epidemics of obesity and type 2 diabetes are major concerns to our health and health care systems and project major public health problems in future generations. In addition to genetics, lifestyle and nutrition, increasing attention is focused on the non-genetic, transgenerational effects of maternal obesity on the offspring, as risk factors for obesity [1]. While the principle asso...

OBJECTIVE To investigate associations between maternal overweight and obesity and infant mortality outcomes, including cause-specific mortality. DESIGN Population based cohort study. SETTING AND PARTICIPANTS 1,857,822 live single births in Sweden 1992-2010. MAIN OUTCOME MEASURES Associations between maternal body mass index (BMI) in early pregnancy and risks of infant, neonatal, and postn...

BACKGROUND Given the long-term adverse sequelae of childhood obesity, identification of early life factors related to fetal growth and childhood obesity is warranted. Investigation on growth and obesity in early life in association with intrauterine exposure to maternal hyperglycemia, a common metabolic pregnancy complication, is of public health significance and clinical implications. OBJECT...

OBJECTIVE Clinical research has shown an increased prevalence of obesity in children with asthma. This study was designed to assess the relationship between asthma and pediatric body mass index (BMI) in a national database and to examine factors that may modify this relationship. DESIGN The cross-sectional relationship between asthma and pediatric BMI and obesity (BMI > or = 85th percentile) ...

Orofacial clefts are the most prevalent birth defects that affect craniofacial structures and implicate genetic and environmental factors in their aetiology. Maternal metabolic state and nutrition have been related to these and other structural malformations, and studies of maternal obesity before pregnancy have shown controversial results about its association with the risk of orofacial clefts...

Europe has the highest proportion of elderly people in the world. Cardiovascular disease, type 2 diabetes, sarcopenia and cognitive decline frequently coexist in the same aged individual, sharing common early risk factors and being mutually reinforcing. Among conditions which may contribute to establish early risk factors, this review focuses on maternal obesity, since the epidemic of obesity i...

The prevalence of overweight and obesity in reproductive-age adults is increasing worldwide. While the effects of either paternal or maternal obesity on gamete health and subsequent fertility and pregnancy have been reported independently, the combination of having both parents overweight/obese on fecundity and offspring health has received minimal attention. Using a 2 × 2 study design in roden...

Obesity during pregnancy has major consequences for maternal and neonatal health, but the long-term effects on the offspring are less clear. It is not known whether the effects observed in animal models are a result of maternal obesity per se or of the high-fat diets used to induce obesity. This investigation aimed to develop a model for the evaluation of the independent effects of cafeteria fe...

Maternal intake of dietary methyl-micronutrients (e.g. folate, choline, betaine and vitamin B-12) during pregnancy is essential for normal maternal and fetal methionine metabolism, and is critical for important metabolic processes including those involved in developmental programming. Maternal obesity and nutrient excess during pregnancy influence developmental programming potentially predispos...

We investigate the magnitude and drivers of income-based inequality adolescent obesity. Using Household, Income Labour Dynamics in Australia survey, we estimate a concentration index –0.1225. also demonstrate that doubled between years 2006 2014. In decomposition analysis, show greatest contributors to observed obesity rates are socioeconomic status maternal status.