The chronic effects of glycine transporter 1 and 2 inhibitors (sarcosine and ALX-1393, respectively) on miniature inhibitory postsynaptic currents were studied in cultured spinal neurons. We found that sarcosine increased the frequency of overall miniature inhibitory postsynaptic currents without affecting the ratio of glycinergic, mixed and GABAergic miniature inhibitory postsynaptic currents,...

With the popularity of urine flow dynamic monitoring and indwelling catheter technologies in animal experiments, the urethral catheterization has become a common technique in scientific research. The miniature pig is considered as one of the major animal species used in scientific research and is increasingly being used as an alternative to a dog or monkey as the nonrodent species of choice in ...

Intracellular microelectrodes inserted into the soma of crayfish stretch receptor neurons record frequent fluctuations of the membrane potential. Time course, amplitude, and interval distribution indicate that they are miniature potentials. At the average resting potential the polarity of the miniature potentials depends on the anion used in the microelectrode: KCl electrodes record depolarizin...

The use of miniature pigs in non-clinical studies for medical drugs or devices has gradually been increasing in recent years. It is anticipated that the use of juvenile miniature pigs in laboratory practice will also increase. Therefore, it is important to investigate various parameters of juvenile miniature pigs. The body surface area (BSA) of an organism is one of the important parameters for...

The deployment of in-situ miniature XRD instruments for planetary exploration requires small focus bright X-ray sources that are physically small, lightweight, robust, and power efficient. Existing miniature X-ray tubes are limited by inefficient thermionic electron sources. We have investigated the potential of carbon nanotube (CNT) field emitters for improving the efficiency and durability of...