Maximal exercise vasodilatation results from the balance between vasoconstricting and vasodilating signals combined with the vascular reactivity to these signals. During maximal exercise with a small muscle mass the skeletal muscle vascular bed is fully vasodilated. During maximal whole body exercise, however, vasodilatation is restrained by the sympathetic system. This is necessary to avoid hy...

Early- and intermediate-term results of the arterial switch operation for D-transposition of the great arteries (D-TGA) are encouraging. However, questions remain about the long-term outcome for these patients, especially with regard to exercise performance. Preliminary studies have demonstrated normal endurance time on treadmills. However, data regarding aerobic capacity and cardiopulmonary fu...

Objectives: Heart rate recovery (HRR) after exercise is clinically important as a predictor of mortality. In addition, HRR an indicator cardiac autonomic activity, since increased vagal activity and diminished sympathetic return the heart to resting conditions exercise. The previous attempts model using polynomial, first-order second-order modelling have produced mixed results. this study, we h...

The amounts of calcium required to achieve various levels of myofibrillar activation in the dog heart were determined by measuring the dependence of myofibrillar calcium binding, myofibrillar adenosinetriphosphatase (ATPase), and isometric tension on free calcium concentration. Myofibrillar ATPase was half-maximal at 2.4 x lO^M free calcium, and tension development was half-maximal at 2.0 x 10~...

PURPOSE To compare peak exercise oxygen consumption (VO2peak) of healthy individuals with asymptomatic individuals with probable heart disease. METHODS Ninety-eight men were evaluated. They were divided into two groups: 1) 39 healthy individuals (group N) with an age range of 50 +/- 4.6 years; and 2) 59 asymptomatic individuals with signs of atherosclerotic and/or hypertensive heart disease (...

introduction: good functional capacity has a high negative predictive value (npv) in patients with known or suspected coronary artery disease (cad) similar to a normal gated myocardial perfusion imaging (gmpi). aim of this study was to evaluate npv of functional capacity during treadmill exercise in patients with normal gmpi in pakistani population. methods: this was a prospective study which ...