ABSTRACT A simple, economical, accurate, precise and reproducible UV-Visible spectrophotometric method for the routine estimation of dasatinib has been developed. The method is based on the formation of a bluish green colored complex by dasatinib in presence of MBTH reagent. The developed colored complex showed λmax at 630 nm. Beer’s law in the concentration range of 10 to 60 μg/ ml. Results of...

A simple and sensitive kinetic method is described for the determination of ketoprofen in pure form, pharmaceuticals and biological fluids. The method utilizes an oxidative- coupling reaction based upon oxidation of 3-methyl-2-benzo-thiazolinone hydrazone hydrochloride (MBTH) with Ce(IV) in presence of HCl, where an electrophilic intermediate (diazonium salt of the reagent) is produced, then co...

The present work describes two new spectrophotometric methods for the determination of bromhexine hydrochloride in bulk and formulations. Method A is based on the reduction of Fe into Fe by the drug followed by the complex formation of Fe with 2, 2’ bipyridyl to form cherry red colored chromogen having maximum absorbance at 510nm and Method B is based on oxidation of 3-methylbenzothiazolinone-2...

A simple, sensitive, selective rapid spectrophotometric method has been developed for the determination of terazosin in pure form, pharmaceutical formulations and blood sample based on the oxidative coupling reaction with MBTH (3-methyl-2-benzothiazolone hydrazone hydrochlorideMethod-A), and Ion association reaction with BPB(Bromophenol Blue-Method-B) reagents at P H_ 4.0 which is extractable a...