The blood of 104 medical inpatients was examined at various intervals during storage for 72 hours using a Coulter S counter. Over this period remarkable stability of the white cell count, red cell count, haemoglobin, and mean cell haemoglobin was demonstrated. This permits a useful interpretation of indices obtained in routine postal samples sent to the laboratory by general practitioners for s...

A constraint satisfaction problem (CSP) is a problem to find an assignment that satisfies given constraints. An interesting approach to CSP is a repair-based method that first generates an initial assignment, then repairs it by minimizing the number of conflicts. Min-conflicts hill climbing (MCHC) and GSAT are typical examples of this approach. A serious problem with this approach is that it is...

In this paper we compare the performance of Minton’s et al. min-conflicts hill-climbing (MCHC) algorithm [8], Wallace and Freuder’s MCHC algorithm [18], Morris’ breakout algorithm (BA) [9, 10], and modified variants of the BA that we developed on static constraint satisfaction problems and recurrent dynamic constraint satisfaction problems (CSPs & rDCSPs). In this study, our results show that t...

The lack of mechanistic explanations for many genotype-phenotype associations identified by GWAS precludes thorough assessment of their impact on human health. Here, we conducted an expression quantitative trait locus (eQTL) mapping analysis in erythroblasts and found erythroid-specific eQTLs for ATP2B4, the main calcium ATPase of red blood cells (rbc). The same SNPs were previously associated ...

We studied the role of the sodium-potassium pump in erythrocytes of 12 patients with sickle cell anemia (SS). Ouabain-binding sites per cell and pump-mediated Rb/K uptake were significantly higher in SS patients than in white or black controls. Ouabainresistant Rb/K influx was also greater than in normal controls or patients with sickle cell trait. Deoxygenation of SS erythrocytes increased oua...

Abstract Background Hematological abnormalities are common features in falciparum malaria but vary among different populations across countries. Therefore, we compared hematological indices and between Plasmodium -infected patients malaria-negative subjects Kosti city of the White Nile State, Sudan. Methods A comparative, cross-sectional study was conducted at Clinical Laboratory Unit Teaching ...

BACKGROUND Red blood cell distribution width (RDW) is a parameter of the complete blood count (CBC) test. Recent evidence suggests that pretreatment RDW is associated with patient survival in various malignant tumors. We explored the association of pretreatment RDW and other red blood cell (RBC) parameters with clinical parameters and assessed their prognostic impact on overall survival (OS) in...

To identify novel genetic loci influencing interindividual variation in red blood cell (RBC) traits in African-Americans, we conducted a genome-wide association study (GWAS) in 2315 individuals, divided into discovery (n = 1904) and replication (n = 411) cohorts. The traits included hemoglobin concentration (HGB), hematocrit (HCT), RBC count, mean corpuscular volume (MCV), mean corpuscular hemo...

Abbreviations: OTA: Ochratoxin-A; hr: Hour; ppm: Parts-Per Million; b.wt.: Body Weight; RBC: Red Blood Cell; Hb: Hemoglobin; PCV: Packed Cell Volume; TLC: Total Leukocyte Count; DLC: Differential Leukocyte Count; MCV: Mean Corpuscular Volume; MCH: Mean Corpuscular Hemoglobin; MCHC: Mean Corpuscular Hemoglobin Concentration; BUN: Blood Urea Nitrogen; ALP: Alkaline Phosphatase; ALT: Alanine Trans...