Metered-dose inhalers (MDIs) and dry powder inhalers play an important role in the treatment of asthma in children of all ages. Yet these devices, which were originally developed for use in adults, interact differently with children. Through childhood there are progressive changes in pharmacokinetic handling and pharmacodynamic effects of inhaled antiasthmatic drugs, in the efficiency and distr...

Background: The metered-dose inhalers (MDIs) currently available for inhaled corticosteroid delivery do not offer an integrated dose counter; therefore, it is difficult to evaluate adherence of patients. The present authors developed a linear regression equation using canister weight to calculate the number of doses actuated from the MDIs. This study aimed to assess medical adherence after the ...

BACKGROUND Hospitalized patients have been shown to make several errors in using metered-dose inhalers (MDIs), which can lead to poor medication delivery. METHODS This study was designed to look at the potential benefit of a respiratory therapist (RT) giving instruction on the use of MDIs to hospitalized patients with obstructive lung disease. A baseline group of 58 patients was observed by a...

RATIONALE The pharmacist charged with the responsibility of drug administration and counseling should have the basic knowledge and skills necessary to demonstrate the use of metered dose inhalers (MDIs) to asthma patients for the maximization of treatment outcomes. OBJECTIVE This study was designed to evaluate the community pharmacists' knowledge of the appropriate use of MDIs in Anambra Stat...

Numerous patients with chronic obstructive pulmonary disease (COPD) and asthma do not use inhaler devices properly, which can contribute to poor disease control. The objective of this study is to assess the technical and safety use of dry powder inhalers (DPIs) versus pressurized metered-dose inhalers (MDIs) in adult patients with COPD or asthma in Lebanon. A concurrent, prospective comparative...

The description by Cheron et al. (1) of an outbreak of hospital-acquired infections due toAlcaligenes denitnfi cans and other nonfermenting gram-negative bacilli was reminiscent of a similar outbreak at our hospital. During a 1-month period there were 11 cases of mixed bacterial infections involving Acinetobacter anitratus, Flavobacterium meningosepticum, and Xanthomonas maltophila in our 15-be...

Several devices have been developed to overcome the need to co-ordinate actuation with inhalation required during use of a pressurised metered dose inhaler (MDI) and to improve drug delivery to the lung. These include spacer attachments for MDIs, dry powder inhalers and breath-actuated MDIs. The breath-actuated Autohaler (3M Pharmaceuticals) is a compact, multidose inhaler device that, unlike d...

PURPOSE The aim of this study was to investigate the effect of immediately loaded mini dental implants (MDIs) used to support mandibular overdentures on the peri-implant bone level as well as patients' related levels of satisfaction and quality of life. MATERIALS AND METHODS Four MDIs were placed in the interforaminal region of 10 completely edentulous patients, and the implants were loaded i...

Electrostatics of pharmaceutical aerosols for inhalation is a relatively new research area. Particle charges have been proposed to potentially influence deposition in the lungs but no conclusive in vivo data have been reported. Investigation of the relationship between the formulation and aerosol charging is required to further explore this area. The modified electrical low pressure impactor (E...