The self-assembly of DNA-conjugated nanoparticles represents a promising avenue toward the design of engineered hierarchical materials. By using DNA to encode nanoscale interactions, macroscale crystals can be formed with mechanical properties that can, at least in principle, be tuned. Here we present in silico evidence that the mechanical response of these assemblies can indeed be controlled, ...

A mechanical assembly is a composition of interrelated parts. Assembly data base stores the geometric models of individual parts, the spatial positions and orientations of the parts in the assembly, and the relationships between parts. An assembly of parts can be represented by its liaison which has a description of its relationships between the various parts in the assembly. The problem is to ...

Molecular self-assembly is a powerful technique for developing novel nanostructures by using noncovalent interactions such as hydrogen bonding, hydrophobic, electrostatic, metal–ligand, p–p and van der Waals interactions. These interactions are highly dynamic and are often delicate due to their relatively weak nature. However, a sufficient number of these weak interactions can yield a stable as...

We report the design of a structurally concise alanine derivative (Ala-hyd) that has a rotationally flexible aromatic N-protecting group for alanine and a hydrazide functionality at its carboxylic end. Ala-hyd requires mechanical agitation (physically stirring, vortexing or sonicating) to form supramolecular hydrogels at medium concentrations (0.4-0.8 wt%). At higher concentrations (>0.8 wt%), ...

Loading conditions and complex geometry have led the cylinder heads to become the most challenging parts of diesel engines. One of the most important durability problems in diesel engines is due to the cracks valves bridge area. The purpose of this study is a thermo-mechanical analysis of cylinder heads of diesel engines using a two-layer viscoplasticity model. In this article, mechanical p...

We investigate the self-assembly of crystals from reconfigurable colloidal building blocks. The building blocks possess the unique ability, inspired by recent experiments, to continuously alter their shape before, during, and after assembly. Using molecular simulations, we report the assembly of a reconfigurable degenerate crystal containing a fractionally filled kagome sublattice. We show that...

When designing mechanical assemblies, assembly tolerance design is an important issue which must be seriously considered by designers. Assembly tolerances reflect functional requirements of assembling, which can be used to control assembling qualities and production costs. This paper proposes a new method for designing assembly tolerance networks of mechanical assemblies. The method establishes...

Purpose: Justify the capability to obtain feasible assembly sequences through an automatic approach based only on contact and interference information between components of a mechanical discrete product, independently of adopted virtual modelling techniques and human intervention. Analysis of assembly information available at early stages of design in virtual model of a product in order to iden...

amyloid-β (aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in alzheimer’s disease pathology.uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...