نتایج جستجو برای: mecom
تعداد نتایج: 105 فیلتر نتایج به سال:
Abstract Objective Myeloid neoplasms (MNs) harboring inv(3)(q21q26)/t(3;3)(q21;q26) or MECOM gene rearrangements as identified by fluorescence in situ hybridization (FISH) are known to carry a poor prognosis. The objective of this study is assess prognostic impact MNs with copy number alterations (CNA) compared inv(3)/t(3;3) rearrangements. We present those initial comparative results and secon...
Live migration of virtual machines has been a powerful tool to facilitate system maintenance, load balancing, fault tolerance, and power-saving, especially in clusters or data centers. Although pre-copy is extensively used to migrate memory data of virtual machines, it cannot provide quick migration with low network overhead but leads to large performance degradation of virtual machine services...
Clonal proliferation in myeloproliferative neoplasms (MPN) is driven by somatic mutations in JAK2, CALR or MPL, but the contribution of inherited factors is poorly characterized. Using a three-stage genome-wide association study of 3,437 MPN cases and 10,083 controls, we identify two SNPs with genome-wide significance in JAK2(V617F)-negative MPN: rs12339666 (JAK2; meta-analysis P=1.27 × 10(-10)...
Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.
Mixed Lineage Leukemia (MLL1) translocations encode fusion proteins retaining the N terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis and thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs); therefore, disruption of an essential MLL1 cofactor would be expec...
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