inhibited by antioxidants, like a-tocopherol and hydrocoumarins, and that reduced glutathione (GSH), an important biological reductant, plays a role in the modulation of the melanogenic process. Melanogenesis, which is catalyzed enzymatically by the key enzyme, tyrosinase, is also influenced by other non-enzymatic factors such as ultraviolet rays and a-melanocytestimulating hormone (a-MSH). In ...

Melanogenesis inhibitors, OH-3984 K1 and K2 were isolated from fermentation broth of Streptomyces sp. OH-3984. OH-3984 K1 and K2 inhibited the melanogenesis of B16 melanoma cells at concentrations of 7.5 and 3.8 micrograms/ml, respectively, whereas inhibition of tyrosinase activity has not been observed. The microbial metabolites showed no antimicrobiological activities against Gram-positive an...

The objective of the study was to determine the effect of role of combination of extracts of Curcuma zedoaria and Aloe vera in reducing melanin synthesis. Yarying concentrations of the extracts of the plan ts were tested for melanogenesis and tyrosinase activity in murine melanoma cells. Extract combinations at a concentrati on of 1-5μ1 showed 50J 50% reduction in melanogenesis without altering...

The objective of the study was to determine the effect of role of combination of extracts of Curcuma zedoaria and Aloe vera in reducing melanin synthesis. Varying concentrations of the extracts of the plants were tested for melanogenesis and tyrosinase activity in murine melanoma cells. Extract combinations at a concentration of 1-5μl showed 50150% reduction in melanogenesis without altering th...

nepeta satureioides boiss. has been used in traditional medicine of eastern countries and is famous for its medicinal properties. the aim of this study was to evaluate the effect of methanol (meoh), n -hexane and dichloromethane (ch 2 cl 2 ) fractions of the extract on melanin synthesis and oxidative stress in b16f10 melanoma cell line. the b16f10 cell line viability after treatment with increa...

Anisaldehyde (4-methoxybenzaldehyde), previously reported as a tyrosinase inhibitor, did not inhibit melanogenesis in cultured B16-F10 melanoma cells but rather enhanced it. This adverse effect of anisaldehyde was accompanied by melanocytotoxicity in a dose-dependent manner up to 2 mM. The melanin content per cell at 1 mM was increased 5-fold compared to control and morphological observations s...

Cholecalciferol (vitamin D) might play a physiological role in photo-induced melanogenesis in human skin. We estimated the levels of 25-hydroxy vitamin D [25(OH)D] before, during, and after Narrow Band Ultraviolet B (NBUVB) radiation in patients of vitiligo and their correlation with NBUVB induced pigmentation. Thirty patients of vitiligo and equal number of age and sex matched controls were re...

To investigate a possible methodology of exploiting herbal medicine and design polytherapy for the treatment skin depigmentation disorder, we have made use Vernonia anthelmintica (L.) Willd., traditional Chinese that has been proven to be effective in treating vitiligo. Here, report extract Willd. effectively enhances melanogenesis responses B16F10. In its compound library, found three ingredie...

Cucurbitacin I (CBI) is a triterpene from a bitter melon called Goya grown in Okinawa, Japan, and directly inhibits both the Tyr-kinase JAK2 and the G protein RAC, leading to the inactivation of PAK1 (RAC/CDC42-activated kinase 1). Bio 30, a propolis produced in New Zealand, contains CAPE (caffeic acid phenethyl ester) as the major anti-cancer ingredient which directly down-regulates RAC, leadi...