Background: Malignant melanoma is a highly metastatic cutaneous cancer and typically refractory to chemotherapy. Deregulated apoptosis has been identified as a major cause of cancer drug resistance, and upregulated expression of the inhibitor of apoptosis protein melanom, an inhibitor of apoptosis (ML-IAP) is frequent in melanoma. Methods: Based on the conclusion that ML-IAP expression contribu...

Introduction: Non-Melanoma Skin Cancer (NMSC) is generally treated in dermatology offices using surgical techniques.

Background and Objectives: Evidence indicate relationships between the sunlight exposure, vitamin D status and non-melanoma skin cancer (NMSC) risk. Vitamin D receptor (VDR) polymorphisms have been linked to metabolic changes in insulin resistance and various cancers. The purpose of this study is to investigate relationships between the sunlight exposure and the NMSC risk. Furthermore, relation...

Cancer-associated fibroblasts (CAFs) play a key role in disease progression and treatment outcome. We used single-cell transcriptomics, CNV analysis, andin situ stainings to elucidate the yet unresolved intra-tumoral CAF heterogeneity melanoma non-melanoma skin cancer (basal squamous cell carcinoma, BCC SCC). identified three major subtypes, with their presence being indicative for tumor malign...

Cancer Nanovaccines In article number 2104849, Mi Liu and co-workers demonstrate a simple universal method to prepare therapeutic preventive cancer nanovaccines based on tumor tissues/cells. Such show both potent efficacy in lung cancer, melanoma, breast cancer. This can be applied make tumor-cell-based for immunotherapy prevention.

There are several types of skin diseases, to protect and keep them healthy from these ailments; an effective efficient diagnosis is required. One the domains used by medical experts diagnose severe class disease imaging. It non-invasive way in which screen abnormal region performs first then dermatologist examines subcutaneous structure forecasts severity lesion. lesions cancer, categorized as ...

Although malignant melanoma is a rare type of skin cancer, it accounts for most cancer-related deaths. Foot lesions may be ignored by both patients and clinicians could therefore lead to advanced disease. An acral also confused with pressure ulcer result in late diagnosis. The need perform biopsy should considered when dealing protracted wounds. In this report, we present the case an 84-year-ol...

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Programmed cell death ligand 1(PD-L1) is expressed as an adaptive immune response to escape anti-tumor mechanisms in various cancer types, including melanoma. However, the complex regulating PD-L1 expression are not well understood. Our aim elucidate signaling and explore candidate inhibitors C8161, SK-MEL-2 lines (human melanoma) B16(mouse melanoma), LN229(human glioblastoma) were used. RT qPC...