Melasma is an acquired hypermelanosis characterized by the development of symmetrical, irregular light-to-dark brown macules and patches on sun-exposed areas of the skin, especially on the skin of the face [1]. It is common among Asian and Hispanic women who are in their third or fourth decades of life [2]. Three patterns of melasma are recognized clinically that are based on the distribution o...

Melasma is an acquired, chronic, and symmetrical hypermelanosis, characterized by brown patches of variable darkness on sun exposed areas of body. There are numerous modalities of treatment currently in use for this disease, of which the chemical peeling is very commonly used. Therefore, the present work was done to see the effect of 82% lactic acid peel in the treatment of melasma. A total num...

BACKGROUND In recent times, tranexamic acid (TA) is claimed to have whitening effects especially for ultraviolet-induced hyperpigmentation including melasma. The aim of our study was to evaluate the efficacy and safety of topical solution of TA and compare it with combined solution of hydroquinone and dexamethasone as the gold standard treatment of melasma in Iranian women. MATERIALS AND METH...

Melasma has significant emotional and psychological effects. These repercussions can be measured using general measures of skin disease. SKINDEX-16 was used in a pilot study (1) to show a significant impact on health-related quality of life (HRQoL) and a correlation with disease severity measured by MASI (Melasma Area Severity Index) (2). A melasma-specific scale, the Melasma Quality of Life Sc...

R ecent data show that melasma lesions have, in addition to increased pigmentation, more elastosis and vascularization than perilesional skin. The stabilized formulation of Kligman preparation has shown significant improvements in the treatment of melasma. However, most of the treatments only target the pigmentation, and none of them has been demonstrated so far to prevent the frequent relapses...

Background and aims: Melasma is an acquired hyperpigmentation on the face, which generally happens in women between the ages of 30 to 35. If treatment is not performed in a timely manner, many cosmetic problems can arise. The aim of this study was to compare the effects of kojic acid and hydroquinone 2% creams for the treatment of melasma. Methods: 100 women with epidermic melasma who were refe...

Exposure to the sun, ultraviolet radiation, and oxidative stress are the chief etiologic factors responsible for melasma. The ingredients of Korean red ginseng powder, which include ginsenoside and phenolic compounds, have antioxidative effects and reduce ultraviolet B-induced pigmentation. This study was designed to evaluate the effectiveness and safety of Korean red ginseng powder in patients...

Background: Melasma is a common hyperpigmentation disorder that has a significant effect on an individual’s quality of life. However, there is no preference-based measurement that reflects quality of life in patients with melasma. Objectives: To assess the impact of melasma on quality of life by using a health status measurement – the Dermatology Life Quality Index (DLQI) – and a preferencebase...

BACKGROUND Melasma is a common hyperpigmentation disorder that has a significant effect on an individual's quality of life. However, there is no preference-based measurement that reflects quality of life in patients with melasma. The objective of this study was to assess the impact of melasma on quality of life by using a health status measurement - the Dermatology Life Quality Index (DLQI) - a...

Melasma is an irregular brown or grayish-brown facial hypermelanosis, often affecting women, especially those living in areas of intense UV radiation. The precise cause of melasma remains unknown; however, there are many possible contributing factors. Because of its dermal component and tendency to relapse, melasma is often difficult to treat. The use of broad-spectrum (UVA + UVB) sunscreen is ...