Nine cases of diffuse membranous glomerulonephritis detected among 90 renal biopsies from children with persistent proteinuria and one necropsy case of a young child who died of chronic membranous glomerulonephritis with uraemia were studied by a variety of techniques. Clinical presentation varies within this single morphological entity and the response to steroid therapy is not yet predictable...

A case of mixed membranous and proliferative glomerulonephritis has been studied by light and electron microscopy. Electron microscopy has shown that the cellular proliferation is mesangial in origin and that there are qualitative and quantitative alterations in the filtration basement membrane. In addition there are numerous examples of direct contact between filtration basement membrane and n...

The transplantation of spleen cells from old NZB/Bl mice with renal disease induced both the structural and the functional changes of membranous glomerulonephritis in young NZB/Bl mice within a few weeks and well in advance of its usual spontaneous occurrence. The development of hypergammaglobulinemia and lymphoid cell hyperplasia in the young mice indicated that immunologically competent cells...

Syphilis is a chronic systemic infectious disease caused by the bacterium Treponema pallidum. Gastric involvement and nephrotic syndrome are uncommon but well documented complications of syphilis, but the co-occurrence of these two complications in the same patient is extremely rare. Thus, because of their nonspecific presentation, suspicion of gastric syphilis (GS) and nephrotic syndrome is es...

Renal biopsies of seven patients with membranous glomerulonephritis were examined by light, electron, and immunofluorescence microscopy. All had characteristic changes of glomerular basement membranes, typically with bright granular membranous fluorescence of IgG and variable deposits of complement. Cellularity was normal or slightly increased due largely to mesangial cell proliferation. These ...

Primary membranous glomerulonephritis (MGN) is a major glomerular disease causing proteinuria in humans (Jones, 1957). It is the prototype of an autoimmune disease (Couser, et al., 1978) characterized by sub-epithelial immune deposits within glomeruli. Its pathogenesis remains still unknown. Immune deposits are formed by IgG4, their respective antigen and complement. The definition of the immun...

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Experimental studies have demonstrated the cardinal role played by the mononuclear phagocyte system in the removal of antigen-antibody complexes. To assess the functional capacity of phagocytes in patients with renal disease, 33 normal subjects, 10 patients with mesangial proliferative glomerulonephritis, 8 patients with membranous nephropathy, and 8 patients with moderately severe chronic rena...