Background. A higher prevalence of cardiovascular disorders has been observed in women after menopause. This study aimed to determine the long-term effects ovariectomy on hemodynamic functions and level nitric oxide metabolites (NOx) heart tissue ovariectomized rats. Methods. Fourteen female Wistar rats were divided into two groups (n=7 each group) control (OVX). OVX rat model was induced using...

Acupoint stimulations are effective in ameliorating symptoms of menopause which is an unavoidable ageing consequence for women. To understand the mechanistic aspects of such treatments, we systematically analyzed the effects of acupoint laser-irradiation and catgut-embedding on the ovariectomy-induced rat metabolic changes using NMR and GC-FID/MS methods. Results showed that ovariectomization (...

The aim of this work was to characterize a mouse model of experimental menopause and cardiovascular aging that closely reflects menopause in women. Senescence accelerated mouse (SAM)-Resistant type 1 (SAMR1, n=30) and SAM-Prone type 8 (SAMP8, n=30) were separated at 5months of age into three groups: 1) sham-operated (Sham); 2) ovariectomized (Ovx); and 3) ovariectomized chronically-treated with...

Background: The effect of ovariectomy and accompanying sudden loss of circulating gonad hormones on spatial learning performance in the young adult rats was examined. We hypothesized that spatial learning and memory in a considerable number of women who undergo a surgical menopause and estrogen deprivation before their natural menopause be impaired. Methods: In this study, we used 26 Wistar ra...

In the industrialized nations, coronary heart disease (CHD) is the most fre­ quent cause of death in women. Before the age of 55, the incidence of coro­ nary events in women is only about one third of that in men. After that, it rises steeply, in women aged 75 it reaches the same rate as in men and is even higher in older age [1]. The 10 years difference between men and women in the clinical ma...

objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...

Background: The effect of ovariectomy and accompanying sudden loss of circulating gonad hormones on spatial learning performance in the young adult rats was examined. We hypothesized that spatial learning and memory in a considerable number of women who undergo a surgical menopause and estrogen deprivation before their natural menopause be impaired. Methods: In this study, we used 26 Wistar rat...

Currently, the neuroprotectant and memory-enhancing agent for menopausal women with metabolic syndrome is required. Based on the advantages of polyphenolics on numerous changes observed in menopause with metabolic syndrome and the encapsulation method, we hypothesized that microencapsulated mulberry fruit extract (MME) could protect brain damage and improve memory impairment in an animal model ...

the goal of this study was to investigate the common clinical chemistry and distribution of xanthine oxidase (xo) in selected tissues of a mouse model of menopause. twenty four nmri female mice were divided into three groups: normal control (nc), and ovariectomized (ovx) groups and an estrogen-treated ovariectomized (ovx+e) group which received subcutaneous injection of estradiol benzoate (2 mg...