Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, TN (M.B., F.P.G.); Merck-Serono, RBM S.p.A. Instituto di Ricerche Biomediche A. Marxer, Colleretto Giacosa, TO, Italy (L.B., S.R.); Merck-Serono, Global Early Development, Darmstadt, Germany (H.D.); and Merck-Serono, Global Early Development, Darmstadt/Global DMPK, Grafing, German...

1Global DMPK, Innovative Medicines, AstraZeneca R&D, Södertälje, Sweden; 2Current affiliation: Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA, USA; 3European Medicines Agency, London, UK; 4Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands; 5M&S, Merck Sharp & Dohme, Oss, The Netherlands. Correspondence: SAG Visser (...

Females Aged 9-21 Years in the United States, 2007-2012 Dongmu Zhang, PhD; Nagesh N. Borse, PhD, MS, BS Pharm; Amit S. Kulkarni, PhD; Linda Niccolai, PhD ScM; Global Health Outcomes, Merck and Co. Inc., West Point, PA; Global Health Outcomes, Agile 1 For Merck and Co., West Point, PA; Global Health Outcomes Vaccine, Merck and Co. Inc., Whitehouse Station, NJ; Yale School of Public Health, Yale ...

without loss of opioid analgesia. Clin Pharmacol Ther 2010; 87:204–11 5. Dahan A, Aarts L, smith TW: Incidence, reversal, and prevention of opioid-induced respiratory depression. ANEsThEsIoLogy 2010; 112:226–38 6. Boom M, Niesters M, sarton E, Aarts L, smith TW, Dahan A: Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des 2012; 18:5994– 6004 7. okie s: A floo...

The Merck pneumococcal (Pn) enzyme-linked immunosorbent assays (ELISAs) for measuring antibodies to 12 serotypes (serotypes 1, 3, 4, 6B, 7F, 8, 9V, 12F, 14, 18C, 19F, and 23F) were validated in 1999. Merck Laboratories developed the Pn assays using 10 microg/ml C polysaccharide, 100 microg/ml Pn polysaccharide (PnPs) 25, and 100 microg/ml PnPs 72 for preadsorption of samples, standards, and con...

Merck & Co., Inc. (Whitehouse Station, NJ), announced that it has successfully completed its $430 million acquisition of Inspire Pharmaceuticals, Inc. (Raleigh, NC). The cash tender offer for all outstanding shares (75.4%) of common stock of Inspire was completed by Monarch Transaction Corp., a wholly owned subsidiary of Merck. The deal, announced in February 2011, allows Merck to expand its op...

n engl j med 364;19 nejm.org may 12, 2011 1880 the steering committee of an imbalance in cancers. They contacted the DSMBs of IMPROVE-IT and SHARP. Merck was not informed of the imbalance. In July 2008, Merck first became aware of the imbalance after database lock and unblinding and provided that information to the SHARP and IMPROVE-IT steering committees, informing them of the need to notify r...

In this case study, DEMO was applied in a real lean six sigma project. The study was conducted in the Merck organisation, a worldwide pharmaceutical company with a research lab and plant for the production of birth control pills in the Netherlands. The case study was conducted at this site and was intended to solve “order reliability” problems. While the general cause of low order reliability w...