To elucidate a protective role of metallothionein (MT) in the manifestation of inorganic mercury toxicity, we studied the susceptibility of MT-null mice to the renal toxicity of mercuric chloride. Because the MT-null (J) mice are a genetic background of 129/Sv strain, the 129/Sv mice were used as wild-type controls. Nine-week-old male MT-null (J) and 129/Sv mice were given subcutaneous injectio...

background : the rapid  development of  the mining and industry activities increased and many toxic metals  in the environment of the earth's crust has been dissipated  and t  has taken  risks to human exposure, inhalation. today evidence of many  diseases associated with environmental  factors  harmful to repellent bio systems is increasing gradually , the majority of these factors  were man-m...

It is well known that mercury is ac cumulated in the kidney and causes renal failure. Mercury has been a subject of extensive study, but a definite mechanism for its biochemical toxicity remains to be elucidated. In a previous paper (1), we reported that mersalyl (mercurial diuretic) had a more powerful stimulatory effect on the lipid peroxidation in renal cortical mito chondria than any other ...

A B S T R A C TIntroduction: Because of more exposure to mercury compounds, the prenatal and postnatal neurotoxic effects of mercury compounds have gained more attention in last decade. The aim of this study was to investigate the effects of mercuric chloride intoxication on spinal cord development during prenatal period. Methods: 36 adult Sprague-dawley rats after observing vaginal mating plaq...

mercury is one of the three major environmental metal poisons, and mercuric chloride is a highly reactive compound which can harm cells by a variety of mechanisms including direct interaction with sulphydryl groups of proteins and enzymes, therefore affecting the enzymatic activity. this study focused on the effect of hg++ on horseradish peroxidase (donor: hydrogen peroxide oxidoreductase, ec 1...

With the advent of modern ophthalmic treatment the use of mercury preparations in ophthalmology has almost been relegated to past history, but mercurous chloride (calomel) is still occasionally used as an insufflation into the eyes, especially in such conditions as phlyctenular keratoconjunctivitis. Recently we saw a case wherein mercuric chloride (HgCl2) was mistaken for calomel and dusted int...

The renal excretion of renin infused intravenously was studied in anesthetized rats. The renin in the urine was adsorbed onto DEAE cellulose and selectively eluted for separate assay on the rat blood pressure preparation. The influence of saline loading, furosemide, mercuric chloride, and maleic acid was determined by following the changes in renin excretion. Both mercuric chloride and maleic a...

abstract heavy metals are the important pollution which there is in the aquatic ecosystems. today, with advances in technology have increased the pollution therefore it is important to assessment the risks. the aim of this study was acute toxicity effects of mercury chloride, lead chloride and zinc chloride in silver carp fish. in this study there were 5 treatments for lead chloride and mercury...

The organomercurial, thimerosal, is at the center of medical controversy as a suspected factor contributing to neurodevelopmental disorders in children. Many neurotoxic effects of thimerosal have been described, but its interaction with principal excitatory and inhibitory neurotransmiter systems is not known. We examined, using electrophysiological recordings, thimerosal effects on GABA and NMD...