background: although cervical cancer mortality has reduced during last years, but it is still leading cause of mortality among women. many efforts have performed to develop new drugs and strategy to cure cervical cancer. mesenchymal stem cells (mscs) have many advantages that make them a suitable choice as a cell therapeutic agent in cancer treatment. there are different transfection methods fo...

Abstract The treatment for glioblastoma (GBM) is maximal safe resection, temozolomide chemotherapy, and radiation therapy. However, with a median survival of only 15 months, new therapies are needed. GBM tumors highly heterogeneous three tumor subtypes, namely classical, proneural, mesenchymal, have been identified. On single cell level, differences even more granular. Casein kinase 2 (CK2), wh...

Introduction: Malignant mesenchymal tumors of the larynx are rare. One type of malignant mesenchymal tumor is synovial sarcoma with unknown histogenesis, which occurs predominantly in the lower extremities of young adults. The head and neck region is a relatively rare location. There are few cases of malignant mesenchymal tumors with laryngeal localization in literature.  Case Report: In this r...

Primary rhabdomyosarcoma (RMS) of the kidney is a rare malignant mesenchymal tumor with an aggressive clinical course. Adult renal RMS is typically a pleomorphic histologic subtype and only a few cases have ever been reported. We herein present a new case of renal RMS of the embryonal histologic subtype in a 26-year-old woman.

Epithelial-mesenchymal plasticity plays a critical role in many solid tumor types as mediator of metastatic dissemination and treatment resistance. In addition, there is also growing appreciation that the epithelial/mesenchymal status immune evasion suppression. A deeper understanding immunological features different has been facilitated by availability large gene expression datasets developmen...

abstract liver neoplasm is not an uncommon disease in asian countries. liposarcoma is a rare mesenchymal malignant tumor which usually originates in the retroperitoneum and extremities. from 1973 till now about 10 cases of primary liver liposarcoma have been reported. we present the eleventh case in a young adult female with uncommon presentation. she suffered from a huge mass in the right port...

Uterine perivascular epithelioid cell tumor is a rare mesenchymal consisting of histologically and immunohistochemically distinctive cells. These tumors’ being rare, having different morphological features similar immunohistochemical expression findings to that some tumors lead diagnostic difficulties misdiagnoses. In the present case report, we aimed discuss traps fell into while diagnosing cu...

OBJECTIVE A hepatic mesenchymal hamartoma is an uncommon benign tumor in children and little is known about the spectrum of its radiological features. The purpose of this study is to describe the spectrum of radiological features of a hepatic mesenchymal hamartoma in children. MATERIALS AND METHODS Thirteen children with a pathologically confirmed hepatic mesenchymal hamartoma (M:F = 7:6; mea...

Objectives: Previous studies used enumerated circulating tumor cells (CTCs) to predict prognosis and therapeutic effect in several types of cancers. However, increasing evidence showed that only enumerated CTCs were not enough to reflect the heterogeneity of tumor. Therefore, we classified different metastasis-potential of CTCs from colorectal cancer patients, in order to improve accuracy of th...

Metastasis is the most powerful predictor of poor outcome of Ewing sarcoma (ES). Thus, identification of new molecules involved in tumor metastasis is of crucial importance to reduce morbidity and mortality of this devastating disease. In this study, we found that miR-124, a highly conserved miRNA, was suppressed in ES tissues and might be associated with tumor metastasis through suppressing it...