background: it has been shown that life style modification may decrease the prevalence of metabolic syndrome, but this intervention has not been reported in community setting. objectives effect of lifestyle modification on prevalence of metabolic syndrome and its components were assessed in an urban population. materials and methods: in 6870 participants of tehran lipid and glucose study aged 2...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: diabetes mellitus is one of the most important epidemics of our era. complications of this disease are diverse and include retinopathy, nephropathy and neuropathy. this study has been designed to evaluate hearing loss patterns in young children suffering from iddm and define risk factors for this complication. ...

Several metabolic alterations accumulate over time along with a reduction in biological fitness, suggesting the existence of a "metabolic clock" that controls aging. Multiple inborn defects in metabolic circuitries accelerate aging, whereas genetic loci linked to exceptional longevity influence metabolism. Each of the nine hallmarks of aging is connected to undesirable metabolic alterations. Th...

The ability to control the rates of metabolic processes in response to changes in the internal or external environment is an indispensable attribute of living cells that must have arisen with life’s origin. This adaptability is necessary for conserving the stability of the intracellular environment (homeostasis), which is, in turn, essential for maintaining an efficient functional state. In the...

Macroautophagy (herein referred to as autophagy) is an evolutionarily conserved mechanism of adaptation to adverse microenvironmental conditions, including limited nutrient supplies. Several sensors interacting with the autophagic machinery have evolved to detect fluctuations in key metabolic parameters. The signal transduction cascades operating downstream of these sensors are highly interconn...

De novo biosynthesis of amino acids uses intermediates provided by the TCA cycle that must be replenished by anaplerotic reactions to maintain the respiratory competency of the cell. Genome-wide expression analyses in Saccharomyces cerevisiae reveal that many of the genes involved in these reactions are repressed in the presence of the preferred nitrogen sources glutamine or glutamate. Expressi...