My purpose in investigating the effect of hemolysis on the accurate assessment of catecholamines and DOPA concentrations by the “Cat-A-Kit” radioenzymic method was to provide a basis for rejecting hemolyzed specimens, and thereby reduce the ever-growing backlog of specimens awaiting analysis in my freezer. I was surprised and disappointed to find that I could not discard hemolyzed samples as be...

In a patient with multiple endocrine neoplasia type 2A (MEN2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine-secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.

Alcohol / Ammonia Antibiotics Bile Acids Biogenic Amines Blood Gases BNP Co-oximetry CSF Endocrine General Serum Chemistry General Therapeutic Drugs Glycohaemoglobin IGF-1 / C Peptide Immunosuppressants Near Patient Testing (POC) Neonatal Bilirubin Plasma Metanephrines Porphyrins Special Lipids Special Therapeutic Drugs Sweat Electrolytes Trace Elements Tumour Markers Urine Chemistry Urine Preg...

This article provides an update about catecholamine metabolism, with emphasis on correcting common misconceptions relevant to catecholamine systems in health and disease. Importantly, most metabolism of catecholamines takes place within the same cells where the amines are synthesized. This mainly occurs secondary to leakage of catecholamines from vesicular stores into the cytoplasm. These store...

BACKGROUND Widely used HPLC methods for quantification of metanephrine and normetanephrine in urine often have long analysis times and are frequently plagued by drug interferences. We describe a gas chromatography-mass spectrometry method designed to overcome these limitations. METHODS Metanephrine and normetanephrine conjugates were converted to unconjugated metanephrine and normetanephrine ...

BACKGROUND Pheochromocytoma and reninoma represent two rare diseases causing hypertension. We here reported a rare case of association between type 2 multiple endocrine neoplasia related bilateral pheochromocytoma and reninoma. Moreover, polymorphism of ACE gene, which is known to be related to an increase of cardiovascular risk, has been found in the same patient. CASE PRESENTATION A 24 year...