Methamphetamine hydrochloride, colloquially referred to as "crystal meth," is a potent psychoactive amphetamine derivate. Methamphetamine produces stimulant effects in the user including increased energy and alertness as well as inducing intense euphoric symptoms and suppressing appetite through its dopaminergic, serotonergic, and adrenergic actions. Use of methamphetamine can adversely affect ...

A preliminary review of substance abuse treatment admission data from 2001-2005 was conducted to explore the use of methamphetamine among American Indians in treatment programs funded by Los Angeles County. Comparisons were made between primary methamphetamine users and users whose primary drug was a substance other than methamphetamine. In that period, the number of American Indians reporting ...

Background: Methamphetamine abuse is a reemerging epidemic in the United States and in many Asian countries. Clinical and preclinical observations suggest that methamphetamine may cause longlasting injury to the brain. In humans, some of the psychiatric conditions, such as paranoid psychosis, may occur not only acutely during methamphetamine exposure, but may persist for months or even years af...

a b s t r a c t abstract- methamphetamine has rapidly become more prominent in iran, which is now second most common drug behind heroin. moreover, initiation of methamphetamine abuse is a major cause of failure of opioid treatment programs such as methadone maintenance treatment. this calls for development of more effective treatment methods for methamphetamine addiction, and especially develop...

Methamphetamine abuse is spreading rapidly throughout the United States and is characterized by significant health consequences. The powerfully rewarding effects of methamphetamine are attributed to multiple neuropharmacological actions such as its ability to block plasma membrane transporters of all monoamines, reduce dopamine transporter expression, and inhibit monoamine oxidase activity whil...

Neuroinflammation induced by activated microglia and astrocytes can be elicited by drugs of abuse. Methamphetamine administration activates glial cells and increases proinflammatory cytokine production, and there is recent evidence of a linkage between glial cell activation and drug abuse-related behavior. We have previously reported that ibudilast (AV411; 3-isobutyryl-2-isopropylpyrazolo-[1,5-...

background: to measure suspected abuse of the methamphetamine (ma) among methadone maintenance treatment (mmt) patients in tehran, we studied all 206 patients who were admitted to mmt program from 2009 to 2015 to andishe-no addiction treatment clinic.  methods: ma presence was screened in one of the random urine samples routinely taken for tests of other drugs.  results: 70 (34.3%) patients wer...

The present study examined childhood histories of attention-deficit hyperactivity disorder (ADHD) in 54 methamphetamine and 12 inhalant abusers using the Wender Utah Rating Scale. The inhalant abusers experienced initial drinking at a younger age than methamphetamine abusers (P=0.038). The Wender Utah Rating Scale score was significantly higher in the inhalant abusers than in the methamphetamin...

AIMS Review the current evidence regarding the prevalence of methamphetamine use among men who have sex with men (MSM) and to evaluate the factors that contribute to methamphetamine use and potential for sexual transmission of HIV and other infectious diseases. METHODS Databased reports address (1) epidemiology of methamphetamine use in MSM; (2) methamphetamine use and risk behaviors for sexu...

Methamphetamine (MA) is a potent psychostimulant drug whose abuse has become a global epidemic in recent years. Firstly, this review article briefly discusses the epidemiology and clinical pharmacology of methamphetamine dependence. Secondly, the article reviews relevant animal literature modeling methamphetamine dependence and discusses possible mechanisms of methamphetamine-induced neurotoxic...