Methamphetamine and related amphetamine compounds are among the most commonly used illicit drugs, with over 35 million users worldwide. In the United States, admissions for methamphetamine treatment have increased dramatically over the past 10 years. Methamphetamine use is prevalent among persons with HIV infection and persons at risk for HIV, particularly among men who have sex with men. In ad...

Little is known about risk factors for depression in methamphetamine users. Using data from 526 adults in the largest psychosocial clinical trial of methamphetamine users conducted to date, this study examined clinical, demographic, and substance use characteristics that predict the presence of a diagnosis of major depressive disorder (MDD) three years after treatment for methamphetamine depend...

recent studies on rodents showed successful treatment outcomes for cocaine dependence by using buprenorphine and naltrexone without the risk of dependence on them. such findings could provide a new hope on treatment of cocaine, methamphetamine or other stimulants dependence. the idea of using these medicines was formed once dr. nora volkow (director of nation institute for drug abuse) based on ...

Gay and bisexual men (GBM) report higher rates of methamphetamine use compared to heterosexual men, and thus have a heightened risk of developing problems from their use. We examined treatment outcomes among GBM clients receiving outpatient counseling at a lesbian, gay, bisexual, transgender and intersex (LGBTI)-specific, harm reduction treatment service in Sydney, Australia. GBM receiving trea...

Methamphetamine dependence; Monoamine oxidase A; MAOA; Polymorphism; VNTR Abstract Background and purpose: Monoamine oxidase A (MAOA, Xp11.3; OMIM: 309850) can modulate the level of neurotransmitters in the central nervous system. A 30 bp variable number of tandem repeat (VNTR) genetic polymorphism on the promoter region of the MAOA can modulate the transcriptional activity of the gene. Associa...

background substance use and affective disorders frequently co-occur, but the role of affective dysregulation in addiction is often overlooked. there is evidence shows that substance – dependent individuals have more problems in regulating their emotions. objectives this study compared two commonly used emotional regulation strategies, cognitive reappraisal and suppression, in opioids and metha...

Substance use disorders, particularly to methamphetamine, are devastating, relapsing diseases that disproportionally affect young people. There is a need for novel, effective and practical treatment strategies that are validated in animal models. Neuromodulation, including deep brain stimulation (DBS) therapy, refers to the use of electricity to influence pathological neuronal activity and has ...

AIMS This review aims to present and interpret evidence that methamphetamine dependence is associated with disorder of brain function that is required for top-down control of behavior. APPROACH Presented here are findings from brain imaging studies of human research participants with histories of chronic methamphetamine abuse in the context of functional consequences and implications for trea...