Staphylococcus aureus is colonized in the human nasal cavity and would contaminate hospital and therapeutic environments. This bacterium has a genetic diversity in terms of resistance to antimicrobial agents. Therefore, the purpose of this study was identificatied of Methicillin and Vancomycin resistant genes in Staphylococcus aureus strains which has been isolated from the nasal cavity. 189 pa...

Abstract Background Positive blood cultures showing Gram positive cocci in clusters signifies either Staphylococcus aureus or the less-virulent coagulase-negative staphylococci. Rapid identification and methicillin susceptibility determination with Xpert MRSA/SA BC assay can improve management of S. bloodstream infection reduce inappropriate antibiotic use. Methods We prospectively evaluated co...

Introduction / objectives We assessed the usefulness of a new automated molecular assay (GenomEra MRSA Confirm, Abacus Diagnostica Oy, Finland), which amplifies simultaneously the marker of methicillin resistance (mecA) and a Staphylococcus aureus-specific DNA segment, in detection of methicillin sensitive and resistant S. aureus (MSSA and MRSA) and other methicillin resistant staphylococci (MR...

tigecycline is a new glycylcycline antibiotic structurally similar to minocycline antibiotic. it has broad spectrum activity, including staphylococcus aureus infections. this is the first study that evaluated the activity of tigecycline against staphylococcus aureus isolated from biological samples in iran. in vitro activity of tigecycline against 160 staphylococcus aureus including 99 methicil...

We tested 148 strains of clinical isolates of methicillin-resistant Staphylococcus aureus against fosfomycin alone and in combination with methicillin, cefamandole, gentamicin, trimethoprim, and vancomycin. Fosfomycin inhibited 90% of the 148 methicillin-resistant S. aureus strains at a concentration of 4 micrograms/ml. Synergism was observed in 97 strains (66%) with fosfomycin-cefamandole and ...

Interstitial nephritis is a recognized complication of methicillin therapy. Hemorrhagic cystitis due to methicillin has not been emphasized. Evidence of hemorrhagic cystitis developed in six patients receiving methicillin therapy and was confirmed by cystoscopy in three of them.

The phenotypic expression of methicillin resistance was studied in a number of clinical isolates and laboratory strains of Staphylococcus aureus. The methicillin-resistant S. aureus strains could be divided into three classes, homogeneous, heterogeneous, and thermosensitive heterogeneous methicillin-resistant S. aureus, on the basis of their plating efficiencies at 30 or 37 degrees C on methici...