methylpyrrole

Epigenetic modifications that govern the gene expression are often overlooked with the design of artificial genetic switches. N-Methylpyrrole-N-methylimidazole (PI) hairpin polyamides are programmable small DNA binding molecules that have been studied in the context of gene regulation. Recently, we synthesized a library of compounds by conjugating PI polyamides with SAHA, a chromatin-modifier. ...

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Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996

J J Kelly E E Baird P B Dervan

Polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids can be combined in antiparallel side-by-side dimeric complexes for sequence-specific recognition in the minor groove of DNA. Six polyamides containing three to eight rings bind DNA sites 5-10 bp in length, respectively. Quantitative DNase I footprint titration experiments demonstrate that affinity maximizes and is...

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Properties of Cu nanoparticles - poly ( N - methylpyrrole ) composites

Isolation of some precursors of 2-methylpyrrole in the Elson–Morgan reaction

2-Alkylation Reactions of Thiophene and 1-Methylpyrrole with Trialkylboranes

The Barrier to Internal Rotation in N-Methylpyrrole-2-aldehyde.

Development of programmable small DNA-binding molecules with epigenetic activity for induction of core pluripotency genes.

Binding site size limit of the 2:1 pyrrole-imidazole polyamide-DNA motif.

Synthesis of DNA-recognizing polyamides containing N-methylpyrrole and N-methylimidazole

Nitrate Ion Selective Electrode Based on Ion Imprinted Poly(N-methylpyrrole)

Determination of the inhibitory effects of N-methylpyrrole derivatives on glutathione reductase enzyme

Syntheses of Some N-Substituted Derivatives of 3-Ethoxy .carbonyl-2-methylpyrrole