Castration in male rats decreased the activities of testosterone and progesterone hydroxylations and reduced the magnitude of spectral change caused by testosterone and progesterone in liver microsomes, accompanying less marked decrease in microsomal P-450 content and NADPH-neotetrazolium reductase activities. The administration of testosterone or methyltestosterone to the castrated rats comple...

6. Spaulding WB: Methyltestosterone therapy for hereditary episodic edema (hereditary angioneurotic edema). Ann Intern Med 53:739, 1960 7. Gelfand JA, Sherins RJ, Alling DW, et al: Treatment of hereditary angioedema with danazol. Reversal of clinical and biochemical abnormalities. N Engl J Med 295:1444, 1976 8. Leimbruger A, Jaques WA, Spaeth RJ: Hereditary angioedema uncomplicated maxillofacia...

17-α-methyltestosterone (MT) is a synthetic hormone used in fish hatcheries to induce male monosex. Snails hold promise as possible test models to assess chemicals acting on the endocrine system. Biomphalaria glabrata is an aquatic gastropod mollusk (Pulmonata, Planorbidae) that can be easily maintained in aquaria, predisposing the species for use in ecotoxicological testing. This study evaluat...

The influence of salinity on toxicity outcomes has been demonstrated for various contaminants, but has received limited attention for endocrine disrupting chemicals (EDCs). Short-term laboratory tests using small-bodied fish are an important tool for evaluating impacts of EDCs on reproduction. Tests have been developed for both freshwater and estuarine/marine species, providing an opportunity t...

The use of steroid hormones containing tagged atoms promises to have an important part in the study of their metabolism. The relative availability of radioactive Cl4 manufactured in the uranium chain-reacting pile at Oak Ridge has facilitated the synthesis of such compounds containing labeled carbon atoms (1). Through the cooperation of Dr. Konrad Dobriner of the Sloan-Kettering Institute for C...

The Organisation for Economic Co-operation and Development has initiated the development of new guidelines for the screening and testing of potential endocrine disruptors. The Hershberger assay is one of the assays selected for validation based on the need for in vivo screening to detect androgen agonists or antagonists by measuring the response of five sex accessory organs and tissues of castr...